\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e7411\u6708\u7b2c2\u9031\uff0f11\u67089\u65e5\u301c11\u670815\u65e5\uff09
\n\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1<\/p>\n
<\/p>\n
\u816b\u760d\u5185\u79d1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u65b9\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u52d5\u304d\u3092\u6bce\u9031\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002<\/p>\n
\u4eca\u9031\u306f11\u670813\u65e5\u306b\u3001\u816b\u760d\u9818\u57df\u306e\u65b0\u85ac5\u6210\u5206\u304c\u4fdd\u967a\u3067\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u4e88\u5b9a\u3067\u3059\u3002\u305d\u306e\u4e2d\u304b\u3089\u3001BRAF \u907a\u4f1d\u5b50\u306b\u7570\u5e38\u306e\u3042\u308b\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\u306e\u98f2\u307f\u85ac\u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6\u3092\u3001\u5c0f\u5150\u3092\u5bfe\u8c61\u3068\u3057\u305f\u6839\u62e0\u306e FIREFLY-1 \u8a66\u9a13\u3068\u3042\u308f\u305b\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500
\n\u25a0 \u4eca\u9031\u306e\u5f53\u79d1\u304b\u3089<\/p>\n
<\/p>\n
\u30fb\u5916\u6765\u5316\u5b66\u7642\u6cd5\u30bb\u30f3\u30bf\u30fc\u306e\u904b\u55b6\u59d4\u54e1\u4f1a
\n\u5916\u6765\u3067\u6297\u304c\u3093\u85ac\u6cbb\u7642\u3092\u884c\u3046\u30bb\u30f3\u30bf\u30fc\u306b\u3064\u3044\u3066\u3001\u95a2\u4fc2\u3059\u308b\u8a3a\u7642\u79d1\u30fb\u90e8\u7f72\u304c\u96c6\u307e\u308a\u3001\u904b\u55b6\u306e\u72b6\u6cc1\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u304c\u3093\u85ac\u7269\u7642\u6cd5\u306e\u591a\u304f\u306f\u3001\u5165\u9662\u3067\u306f\u306a\u304f\u5916\u6765\u3067\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u5b89\u5168\u306b\u7d9a\u3051\u308b\u306b\u306f\u3001\u533b\u5e2b\u3060\u3051\u3067\u306a\u304f\u770b\u8b77\u5e2b\u3001\u85ac\u5264\u5e2b\u3001\u4e8b\u52d9\u306e\u65b9\u3092\u542b\u3081\u305f\u4f53\u5236\u3065\u304f\u308a\u304c\u6b20\u304b\u305b\u307e\u305b\u3093\u3002<\/p>\n
<\/p>\n
\u30fb\u5316\u5b66\u7642\u6cd5\u30ec\u30b8\u30e1\u30f3\u306e\u9662\u5185\u5be9\u67fb\uff08\u4e8b\u524d\u5be9\u67fb\uff09
\n\u65b0\u3057\u304f\u4f7f\u3044\u305f\u3044\u6297\u304c\u3093\u85ac\u306e\u7d44\u307f\u5408\u308f\u305b\uff08\u30ec\u30b8\u30e1\u30f3\uff09\u306b\u3064\u3044\u3066\u3001\u9662\u5185\u3067\u4f7f\u3046\u524d\u306b\u3001\u6839\u62e0\u3084\u6295\u4e0e\u91cf\u3001\u526f\u4f5c\u7528\u3078\u306e\u5099\u3048\u3092\u78ba\u304b\u3081\u308b\u4e8b\u524d\u5be9\u67fb\u3092\u884c\u3044\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u6297\u304c\u3093\u85ac\u306e\u6295\u4e0e\u91cf\u3084\u6295\u4e0e\u65e5\u3001\u4f75\u7528\u3059\u308b\u652f\u6301\u7642\u6cd5\u306e\u85ac\u306f\u3001\u30ec\u30b8\u30e1\u30f3\u3068\u3057\u3066\u75c5\u9662\u3067\u767b\u9332\u3055\u308c\u3066\u304b\u3089\u4f7f\u308f\u308c\u307e\u3059\u3002\u8aa4\u6295\u4e0e\u3092\u9632\u3050\u305f\u3081\u306e\u5927\u5207\u306a\u4ed5\u7d44\u307f\u3067\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u306b\u95a2\u3059\u308b\u9662\u5185\u30bb\u30df\u30ca\u30fc
\n\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\u306e\u6642\u9593\u5e2f\u306b\u3001\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u306b\u95a2\u3059\u308b\u9662\u5185\u30bb\u30df\u30ca\u30fc\u304c\u958b\u304b\u308c\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u6271\u3044\u65b9\u306f\u3001\u65b0\u3057\u3044\u691c\u67fb\u3084\u85ac\u304c\u52a0\u308f\u308b\u305f\u3073\u306b\u5c11\u3057\u305a\u3064\u5909\u308f\u308a\u307e\u3059\u3002\u95a2\u308f\u308b\u8077\u7a2e\u3067\u77e5\u8b58\u3092\u305d\u308d\u3048\u3066\u304a\u304f\u3053\u3068\u304c\u3001\u691c\u67fb\u7d50\u679c\u3092\u6cbb\u7642\u306b\u3064\u306a\u3052\u308b\u52a9\u3051\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u6d88\u5316\u7ba1\u30fb\u809d\u80c6\u81b5\u306e\u5316\u5b66\u7642\u6cd5\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9
\n\u6d88\u5316\u5668\u306e\u304c\u3093\u306b\u3064\u3044\u3066\u3001\u5916\u79d1\u3068\u816b\u760d\u5185\u79d1\u304c\u96c6\u307e\u308a\u3001\u85ac\u7269\u7642\u6cd5\u306e\u65b9\u91dd\u3092\u76f8\u8ac7\u3057\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u624b\u8853\u306e\u524d\u5f8c\u306b\u884c\u3046\u85ac\u7269\u7642\u6cd5\u3067\u306f\u3001\u5916\u79d1\u306e\u8996\u70b9\u3068\u85ac\u7269\u7642\u6cd5\u306e\u8996\u70b9\u3092\u6301\u3061\u5bc4\u3063\u3066\u3001\u6cbb\u7642\u306e\u9806\u756a\u3084\u6642\u671f\u3092\u6c7a\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u203b \u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u30fb\u75c7\u4f8b\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u542b\u307f\u307e\u305b\u3093\u3002\u5f53\u79d1\u306e\u6d3b\u52d5\u3092\u4e00\u822c\u5316\u3057\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500
\n\u25a0 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\u30cb\u30e5\u30fc\u30b9<\/p>\n
<\/p>\n
11\u67086\u65e5\u306e\u4e2d\u592e\u793e\u4f1a\u4fdd\u967a\u533b\u7642\u5354\u8b70\u4f1a\uff08\u4e2d\u533b\u5354\uff09\u7dcf\u4f1a\u3067\u3001\u65b0\u533b\u85ac\u54c116\u6210\u306e\u85ac\u4fa1\u53ce\u8f09\u304c\u4e86\u627f\u3055\u308c\u307e\u3057\u305f\u3002\u53ce\u8f09\u4e88\u5b9a\u65e5\u306f11\u670813\u65e5\u3067\u3001\u3053\u306e\u3046\u3061\u816b\u760d\u9818\u57df\u306e\u85ac\u306f5\u6210\u5206\u3067\u3059\u3002<\/p>\n
<\/p>\n
\u30fbBRAF \u907a\u4f1d\u5b50\u5909\u7570\u30fb\u878d\u5408\u907a\u4f1d\u5b50\u3092\u6709\u3059\u308b\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\u306b\u3001\u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6\u3014\u4fdd\u967a\u9069\u7528\uff08\u85ac\u4fa1\u53ce\u8f09\u4e88\u5b9a 2026\u5e7411\u670813\u65e5\uff09\uff0f\u85ac\u4e8b\u627f\u8a8d 2026\u5e749\u670816\u65e5\u3015 <\/p>\n \u30fb\u540c\u3058\u65e5\u306b\u53ce\u8f09\u4e88\u5b9a\u306e\u816b\u760d\u9818\u57df\u306e\u85ac\u3014\u4fdd\u967a\u9069\u7528\uff08\u85ac\u4fa1\u53ce\u8f09\u4e88\u5b9a 2026\u5e7411\u670813\u65e5\uff09\u3015 \u51fa\u5178\uff1a\u539a\u751f\u52b4\u50cd\u7701 \u4e2d\u533b\u5354 \u7dcf\u4f1a\uff08\u7b2c661\u56de\u30012026\u5e7411\u67086\u65e5\uff09\u8cc7\u6599 \u7dcf\uff0d\uff12\u300c\u533b\u85ac\u54c1\u306e\u65b0\u898f\u85ac\u4fa1\u53ce\u8f09\u306b\u3064\u3044\u3066<\/a>\u300d<\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n \u518d\u767a\u30fb\u96e3\u6cbb\u6027\u306e\u5c0f\u5150\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\u306b\u5bfe\u3059\u308b\u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6 \u2015 \u7b2c\u2161\u76f8 FIREFLY-1 \u8a66\u9a13 <\/p>\n \u30fb\u518d\u767a\u307e\u305f\u306f\u6cbb\u7642\u62b5\u6297\u6027\u306e\u5c0f\u5150\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\u304c\u5bfe\u8c61\u3067\u3059\u3002\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b Arm 1 \u306b\u306f BRAF \u907a\u4f1d\u5b50\u306b\u7570\u5e38\u306e\u3042\u308b77\u4f8b\u3001Arm 1 \u306e\u767b\u9332\u7d42\u4e86\u5f8c\u306b\u6cbb\u7642\u6a5f\u4f1a\u3092\u63d0\u4f9b\u3059\u308b\u62e1\u5927\u30b3\u30db\u30fc\u30c8\uff08Arm 2\uff09\u306b\u306f RAF \u907a\u4f1d\u5b50\u306b\u7570\u5e38\u306e\u3042\u308b60\u4f8b\u304c\u767b\u9332\u3055\u308c\u307e\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002 <\/p>\n \u81e8\u5e8a\u7684\u610f\u7fa9\uff1aBRAF \u306b\u7570\u5e38\u304c\u3042\u308b\u518d\u767a\u30fb\u96e3\u6cbb\u6027\u306e\u5c0f\u5150\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\u3067\u3001\u90311\u56de\u306e\u98f2\u307f\u85ac\u306b\u3088\u308b\u816b\u760d\u7e2e\u5c0f\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u6bd4\u8f03\u5bfe\u7167\u306e\u306a\u3044\u5358\u7fa4\u8a66\u9a13\u3067\u3001\u6284\u9332\u306e\u7bc4\u56f2\u3067\u306f\u751f\u5b58\u671f\u9593\u306e\u7d50\u679c\u306f\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n <\/p>\n \u51fa\u5178\uff08PubMed \u53ce\u8f09\uff0fPMID: 37978284\uff09\uff1aDOI: 10.1038\/s41591-023-02668-y<\/a> \uff08Kilburn LB, et al. Nat Med 2024;30(1):207-217\uff09\uff0f\u8a02\u6b63\u8a18\u4e8b\uff08PMID: 40240838\uff09\uff1aDOI: 10.1038\/s41591-025-03709-4<\/a><\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n \u301011\/21\uff08\u571f\uff09\u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a \u4e2d\u56fd\u30fb\u56db\u56fd\u5730\u533a\u30bb\u30df\u30ca\u30fc\u300111\/22\uff08\u65e5\uff09Best of ESMO 2026\u3011\uff08\u524d\u53f7\u304b\u3089\u7d99\u7d9a\uff09 <\/p>\n \u301012\/4\uff08\u91d1\uff09\u65e5\u672c\u907a\u4f1d\u5b50\u8a3a\u7642\u5b66\u4f1a \u516c\u958b\u30b7\u30f3\u30dd\u30b8\u30a6\u30e02026\u300c\u30b2\u30ce\u30e0\u533b\u7642\u306e\u6b21\u306a\u308b\u30b9\u30c6\u30fc\u30b8\u300d\u3011\uff08\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u30fb\u5b66\u751f\u306f\u53c2\u52a0\u8cbb\u7121\u6599\uff0f\u524d\u53f7\u304b\u3089\u7d99\u7d9a\uff09 <\/p>\n \u301012\/12\uff08\u571f\uff09\u5e02\u6c11\u516c\u958b\u8b1b\u5ea7\u300c\u304c\u3093\u60a3\u8005\u30fb\u3054\u5bb6\u65cf\u30fb\u5730\u57df\u306e\u7686\u69d8\u306b \u6700\u65b0\u533b\u7642\u60c5\u5831\u3092\u304a\u5c4a\u3051\u3057\u307e\u3059 \uff5e\u514d\u75ab\u7642\u6cd5\u30fb\u500b\u5225\u5316\u533b\u7642\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u306e\u6700\u524d\u7dda\uff5e\u300d\u3011\uff08\u53c2\u52a0\u7121\u6599\u30fb\u8981\u4e8b\u524d\u4e88\u7d04\u30fb\u5148\u7740250\u540d\uff09 <\/p>\n \u30102027\u5e743\/18\uff08\u6728\uff09\u301c20\uff08\u571f\uff09\u7b2c24\u56de \u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\uff08JSMO2027\uff09\u53c2\u52a0\u767b\u9332\u306e\u53d7\u4ed8\u304c\u59cb\u307e\u308a\u307e\u3057\u305f\u3011\uff08\u5b66\u751f\u30fb\u521d\u671f\u7814\u4fee\u533b\u306f\u53c2\u52a0\u8cbb\u7121\u6599\uff09 <\/p>\n \u5f53\u79d1\u306e\u898b\u5b66\u30fb\u5b9f\u7fd2\u30fb\u9032\u8def\u76f8\u8ac7\u306f\u968f\u6642\u53d7\u3051\u4ed8\u3051\u3066\u3044\u307e\u3059 <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n BRAF \u3068\u3044\u3046\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306f\u3001\u4eca\u9031\u7d39\u4ecb\u3057\u305f\u5c0f\u5150\u306e\u8133\u816b\u760d\u3060\u3051\u3067\u306a\u304f\u3001\u60aa\u6027\u9ed2\u8272\u816b\u3084\u5927\u8178\u304c\u3093\u3001\u80ba\u304c\u3093\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u304c\u3093\u3067\u898b\u3064\u304b\u308a\u307e\u3059\u3002\u540c\u3058\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u3067\u3082\u3001\u304c\u3093\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u85ac\u306e\u52b9\u304d\u65b9\u3084\u4f7f\u3044\u65b9\u304c\u7570\u306a\u308b\u3053\u3068\u304c\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u306e\u304c\u3093\u3067\u8a66\u9a13\u304c\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n \u816b\u760d\u5185\u79d1\u3067\u306f\u3001\u304c\u3093\u306e\u7a2e\u985e\u3068\u907a\u4f1d\u5b50\u306e\u7570\u5e38\u306e\u4e21\u65b9\u3092\u898b\u306a\u304c\u3089\u6cbb\u7642\u3092\u8003\u3048\u307e\u3059\u3002\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u7d50\u679c\u3092\u691c\u8a0e\u3059\u308b\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\u3082\u3001\u305d\u306e\u8003\u3048\u65b9\u3092\u5b9f\u969b\u306b\u4f7f\u3046\u5834\u3067\u3059\u3002\u81d3\u5668\u3054\u3068\u306e\u77e5\u8b58\u3068\u907a\u4f1d\u5b50\u306e\u77e5\u8b58\u3092\u3064\u306a\u3044\u3067\u3044\u304f\u3068\u3053\u308d\u306b\u3001\u3053\u306e\u5206\u91ce\u306e\u9762\u767d\u3055\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e7411\u6708\u7b2c2\u9031\uff0f11\u67089\u65e5\u301c11\u670815\u65e5\uff09 \u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1 \u816b\u760d\u5185\u79d1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u65b9\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u52d5\u304d\u3092\u6bce\u9031\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002 […]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[],"class_list":["post-2798","post","type-post","status-publish","format-standard","hentry","category-information"],"publishpress_future_action":{"enabled":false,"date":"2026-11-17 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\n\u30aa\u30b8\u30a7\u30f3\u30c0\u9320100mg\u30fb\u540c\u30c9\u30e9\u30a4\u30b7\u30ed\u30c3\u30d7300mg\uff08\u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6\u3001IPSEN\uff09\u306f\u90311\u56de\u98f2\u3080\u85ac\u3067\u3001\u4f53\u8868\u9762\u7a4d\u306b\u5fdc\u3058\u3066\u91cf\u3092\u6c7a\u3081\u307e\u3059\u3002\u4f53\u306e\u5c0f\u3055\u3044\u304a\u5b50\u3055\u3093\u5411\u3051\u306b\u3001\u30c9\u30e9\u30a4\u30b7\u30ed\u30c3\u30d7\u306e\u5264\u5f62\u3082\u3042\u308a\u307e\u3059\u3002\u627f\u8a8d\u306e\u6bb5\u968e\u306f\u7b2c11\u53f7\u3067\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002
\n\u4e2d\u533b\u5354\u306e\u8cc7\u6599\u306b\u3088\u308b\u3068\u3001\u6709\u52b9\u6027\u306e\u8a55\u4fa1\u306f\u6d77\u5916\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u57fa\u3065\u3044\u3066\u304a\u308a\u3001\u8a66\u9a13\u306b\u65e5\u672c\u4eba\u306e\u60a3\u8005\u3055\u3093\u306f\u7d44\u307f\u5165\u308c\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b\u306f\u3001\u5c0f\u5150\u3067\u591a\u3044\u8133\u816b\u760d\u3067\u3059\u3002BRAF \u306e\u7570\u5e38\u306b\u306f\u3001\u7279\u5b9a\u306e\u5834\u6240\u304c\u7f6e\u304d\u63db\u308f\u308b\u300c\u5909\u7570\u300d\uff08V600E \u306a\u3069\uff09\u3068\u3001BRAF \u304c\u5225\u306e\u907a\u4f1d\u5b50\u3068\u3064\u306a\u304c\u308b\u300c\u878d\u5408\u907a\u4f1d\u5b50\u300d\u304c\u3042\u308a\u307e\u3059\u3002\u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6\u306f\u305d\u306e\u4e21\u65b9\u3092\u5bfe\u8c61\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3069\u3061\u3089\u306e\u7570\u5e38\u304c\u3042\u308b\u304b\u306f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u8abf\u3079\u307e\u3059\u3002
\n\u51fa\u5178\uff1a\u539a\u751f\u52b4\u50cd\u7701 \u4e2d\u533b\u5354 \u7dcf\u4f1a\uff08\u7b2c661\u56de\u30012026\u5e7411\u67086\u65e5\uff09\u8cc7\u6599 \u7dcf\uff0d\uff12\u300c\u533b\u85ac\u54c1\u306e\u65b0\u898f\u85ac\u4fa1\u53ce\u8f09\u306b\u3064\u3044\u3066<\/a>\u300d \uff0f PMDA\u300c\u627f\u8a8d\u54c1\u76ee\u4e00\u89a7\uff08\u65b0\u533b\u85ac\u54c1\uff1a2026\u5e749\u6708\u5206\uff09<\/a>\u300d<\/p>\n
\n\u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6\u306e\u307b\u304b\u306b\u3001\u6b21\u306e4\u6210\u5206\u304c\u53ce\u8f09\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002\u3044\u305a\u308c\u3082\u904e\u53bb\u306e\u53f7\u3067\u53d6\u308a\u4e0a\u3052\u3066\u3044\u307e\u3059\u3002
\n\u30fb\u30ad\u30a4\u30b8\u30a7\u30af\u30c8\u914d\u5408\u76ae\u4e0b\u6ce8\uff1a\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u3068\u30d9\u30e9\u30d2\u30a2\u30eb\u30ed\u30cb\u30c0\u30fc\u30bc \u30a2\u30eb\u30d5\u30a1\u306e\u914d\u5408\u5264\u3002\u30da\u30e0\u30d6\u30ed\u30ea\u30ba\u30de\u30d6\u3092\u70b9\u6ef4\u3067\u306f\u306a\u304f\u76ae\u4e0b\u6ce8\u5c04\u3067\u6295\u4e0e\u3059\u308b\u88fd\u5264\u3067\u3059\uff08\u627f\u8a8d 2026\u5e749\u670816\u65e5\uff0f\u7b2c8\u53f7\u3067\u90e8\u4f1a\u5be9\u8b70\u306e\u6bb5\u968e\u3092\u7d39\u4ecb\uff09\u3002
\n\u30fb\u30a8\u30c8\u30ab\u30de\u9320\uff1a\u30ab\u30df\u30bc\u30b9\u30c8\u30e9\u30f3\u30c8\u3002\u5185\u5206\u6ccc\u7642\u6cd5\u4e2d\u306b ESR1 \u907a\u4f1d\u5b50\u5909\u7570\u304c\u78ba\u8a8d\u3055\u308c\u3001\u75be\u60a3\u9032\u884c\u304c\u8a8d\u3081\u3089\u308c\u306a\u3044\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\u967d\u6027\u304b\u3064HER2\u9670\u6027\u306e\u624b\u8853\u4e0d\u80fd\u53c8\u306f\u518d\u767a\u4e73\u764c\uff08\u627f\u8a8d 2026\u5e746\u670819\u65e5\uff0f\u7b2c3\u53f7\u3067\u7d39\u4ecb\uff09\u3002
\n\u30fb\u30a8\u30e9\u30d2\u30a2\u70b9\u6ef4\u9759\u6ce8\uff1a\u30df\u30eb\u30d9\u30c4\u30ad\u30b7\u30de\u30d6 \u30bd\u30e9\u30d6\u30bf\u30f3\u30b7\u30f3\u3002\u8449\u9178\u53d7\u5bb9\u4f53\u03b1\u967d\u6027\u306e\u767d\u91d1\u7cfb\u6297\u60aa\u6027\u816b\u760d\u5264\u62b5\u6297\u6027\u306e\u518d\u767a\u5375\u5de3\u764c\uff08\u627f\u8a8d 2026\u5e749\u670816\u65e5\uff0f\u7b2c11\u53f7\u3067\u7d39\u4ecb\uff09\u3002
\n\u30fb\u30e2\u30c7\u30fc\u30bd\u30ab\u30d7\u30bb\u30eb\uff1a\u30c9\u30eb\u30c0\u30d3\u30d7\u30ed\u30f3\u3002\u3073\u307e\u3093\u6027\u6b63\u4e2d\u81a0\u816b\uff08\u627f\u8a8d 2026\u5e749\u670816\u65e5\uff0f\u7b2c12\u53f7\u3067\u540d\u524d\u306e\u307f\u7d39\u4ecb\uff09\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u65e5\u672c\u3067\u306f\u539f\u5247\u3068\u3057\u3066\u3001\u85ac\u4e8b\u627f\u8a8d\u306e\u3042\u3068\u85ac\u4fa1\u57fa\u6e96\u306b\u53ce\u8f09\u3055\u308c\u3066\u3001\u306f\u3058\u3081\u3066\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u4eca\u56de\u306e\u53ce\u8f09\u3067\u306f\u30019\u670816\u65e5\u627f\u8a8d\u306e\u85ac\u306f\u7d042\u304b\u6708\u30016\u670819\u65e5\u627f\u8a8d\u306e\u30a8\u30c8\u30ab\u30de\u306f\u7d045\u304b\u6708\u3067\u53ce\u8f09\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3014\u6982\u7b97\u3015\u3002<\/p>\n
\n\u25a0 \u4eca\u9031\u306e\u4e00\u5831\uff08\u6ce8\u76ee\u8ad6\u6587\uff09\u3014\u5c0f\u5150\u4f4e\u60aa\u6027\u5ea6\u795e\u7d4c\u81a0\u816b \u2015 \u30c8\u30dc\u30e9\u30d5\u30a7\u30cb\u30d6\u306e\u6839\u62e0\u3015<\/p>\n
\nNat Med. 2024;30(1):207-217\uff0f\u7b2c\u2161\u76f8\u30fb\u5358\u7fa4\u8a66\u9a13\uff08NCT04775485\uff09<\/p>\n
\n\u30fb\u8a66\u9a13\u3067\u306e\u7528\u91cf\u306f\u90311\u56de 420mg\/m\u00b2\uff08\u4e0a\u9650600mg\uff09\u306e\u5185\u670d\u3067\u3059\u3002
\n\u30fb\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u72ec\u7acb\u5224\u5b9a\u306b\u3088\u308b\u594f\u52b9\u7387\uff08RANO-HGG \u57fa\u6e96\uff09\u306f67%\u3067\u3001\u4e8b\u524d\u306b\u5b9a\u3081\u305f\u57fa\u6e96\u3092\u6e80\u305f\u3057\u307e\u3057\u305f\u3002\u594f\u52b9\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f16.6\u304b\u6708\u3067\u3057\u305f\u3002\u5c0f\u3055\u306a\u7e2e\u5c0f\u3082\u594f\u52b9\u306b\u542b\u3081\u308b\u5c0f\u5150\u5411\u3051\u306e RAPNO \u57fa\u6e96\u3067\u306f\u3001\u594f\u52b9\u738751%\u3001\u594f\u52b9\u671f\u9593\u306e\u4e2d\u592e\u502413.8\u304b\u6708\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002
\n\u30fb\u5b89\u5168\u6027\u306f\u6cbb\u7642\u3092\u53d7\u3051\u305f137\u4f8b\u3067\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u4e3b\u306a\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306f\u3001\u9aea\u306e\u8272\u306e\u5909\u531676%\u3001CK\uff08\u30af\u30ec\u30a2\u30c1\u30f3\u30ad\u30ca\u30fc\u30bc\uff09\u4e0a\u660756%\u3001\u8ca7\u884049%\u3067\u3057\u305f\u3002Grade 3\u4ee5\u4e0a\u306e\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306f42%\u3001\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u4e2d\u6b62\u306f9\u4f8b\uff087%\uff09\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002<\/p>\n
\n\u25a0 \u5b66\u4f1a\u30fb\u30bb\u30df\u30ca\u30fc\uff0f\u884c\u4e8b<\/p>\n
\n\u4e2d\u56fd\u30fb\u56db\u56fd\u5730\u533a\u30bb\u30df\u30ca\u30fc\u306e\u767b\u9332\u7de0\u5207\u306f11\u670816\u65e5\u3067\u3059\u3002Best of ESMO 2026 \u306f ESMO 2026 \u306e\u6ce8\u76ee\u6f14\u984c\u3092\u65e5\u672c\u8a9e\u3067\u89e3\u8aac\u3059\u308b\u4f1a\u3067\u3001\u5b66\u751f\u30fb\u521d\u671f\u7814\u4fee\u533b\u306f\u7121\u6599\u3067\u53c2\u52a0\u3067\u304d\u307e\u3059\u300211\u670822\u65e5\u306e\u30e9\u30a4\u30d6\u914d\u4fe1\u306e\u3042\u3068\u300112\u67087\u65e5\u304b\u30892027\u5e744\u67087\u65e5\u307e\u3067\u30aa\u30f3\u30c7\u30de\u30f3\u30c9\u3067\u3082\u8996\u8074\u3067\u304d\u307e\u3059\u3002
\n\u30fb\u4e2d\u56fd\u30fb\u56db\u56fd\u5730\u533a\u30bb\u30df\u30ca\u30fc \u53c2\u52a0\u767b\u9332\uff1ahttps:\/\/www.google.com\/url?q=https:\/\/forms.gle\/9gQiBqVmjwhmqHci7&source=gmail&ust=1794339167211000&sa=E<\/a>
\n\u30fbBest of ESMO 2026 \u7533\u8fbc\u30fb\u30d7\u30ed\u30b0\u30e9\u30e0\uff1ahttps:\/\/www.google.com\/url?q=https:\/\/medicalprime.jp\/event\/boe2026\/&source=gmail&ust=1794339167211000&sa=E<\/a><\/p>\n
\n\u4f1a\u5834\u53c2\u52a0\u306b\u52a0\u3048\u3066\u5f53\u65e5\u306e\u30e9\u30a4\u30d6\u914d\u4fe1\u3068\u5f8c\u65e5\u306e\u30aa\u30f3\u30c7\u30de\u30f3\u30c9\u914d\u4fe1\uff0812\u670811\u65e5\u301c2027\u5e741\u670812\u65e5\uff09\u304c\u3042\u308a\u3001\u5b66\u751f\u306f\u53c2\u52a0\u767b\u9332\u3092\u3059\u308c\u3070\u7121\u6599\u3067\u53c2\u52a0\u3067\u304d\u307e\u3059\u3002
\n\u30fb\u30d7\u30ed\u30b0\u30e9\u30e0\uff1ahttps:\/\/www.google.com\/url?q=http:\/\/www.gene-dt.jp\/forum.html&source=gmail&ust=1794339167211000&sa=E<\/a>
\n\u30fb\u53c2\u52a0\u767b\u9332\uff1ahttps:\/\/www.google.com\/url?q=https:\/\/www.gakkai-web.net\/p\/mp\/jsgdt\/new2.php&source=gmail&ust=1794339167211000&sa=E<\/a><\/p>\n
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\n\u30fb\u4f1a\u671f\uff1a2027\u5e743\u670818\u65e5\uff08\u6728\uff09\u301c20\u65e5\uff08\u571f\uff09
\n\u30fb\u4f1a\u5834\uff1a\u77f3\u5ddd\u770c\u7acb\u97f3\u697d\u5802 \u307b\u304b\uff08\u77f3\u5ddd\u770c\u91d1\u6ca2\u5e02\uff09
\n\u30fb\u65e9\u671f\u53c2\u52a0\u767b\u9332\uff1a2026\u5e7411\u67084\u65e5\uff08\u6c34\uff09\u6b63\u5348\u301c2027\u5e742\u67082\u65e5\uff08\u706b\uff09\u6b63\u5348
\n\u30fb\u30db\u30fc\u30e0\u30da\u30fc\u30b8\uff1ahttps:\/\/www.google.com\/url?q=https:\/\/www.c-linkage.co.jp\/jsmo2027\/&source=gmail&ust=1794339167212000&sa=E<\/a>
\n\u30fb\u53c2\u52a0\u767b\u9332\uff1ahttps:\/\/www.google.com\/url?q=https:\/\/www.c-linkage.co.jp\/jsmo2027\/registration.html&source=gmail&ust=1794339167212000&sa=E<\/a><\/p>\n
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