\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e748\u6708\u7b2c4\u9031\uff0f8\u670824\u65e5\u301c8\u670830\u65e5\uff09
\n\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1<\/p>\n
<\/p>\n
\u816b\u760d\u5185\u79d1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u65b9\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u306e\u6d3b\u52d5\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u4e16\u306e\u4e2d\u306e\u52d5\u304d\uff08\u8ad6\u6587\u30fb\u5b66\u4f1a\u30fb\u5236\u5ea6\uff09\u3092\u3001\u6bce\u9031\u307e\u3068\u3081\u3066\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002<\/p>\n
\u4eca\u9031\u306f\u5f53\u79d1\u3067\u5b66\u751f\u306e\u7814\u7a76\u6307\u5c0e\u304c\u7d9a\u3044\u305f\u4e00\u9031\u9593\u3067\u3057\u305f\u3002\u4e16\u306e\u4e2d\u306e\u52d5\u304d\u3068\u3057\u3066\u306f\u3001\u9577\u3089\u304f\u300c\u85ac\u3067\u72d9\u3048\u306a\u3044\u300d\u3068\u8a00\u308f\u308c\u3066\u304d\u305f RAS \u3092\u6a19\u7684\u306b\u3057\u305f\u85ac\u304c\u3001\u81b5\u304c\u3093\u3067\u627f\u8a8d\u3055\u308c\u305f\u3068\u3044\u3046\u8a71\u984c\u3092\u53d6\u308a\u4e0a\u3052\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500
\n\u25a0 \u4eca\u9031\u306e\u5f53\u79d1\u304b\u3089<\/p>\n
<\/p>\n
\u30fb\u539f\u767a\u4e0d\u660e\u304c\u3093\u30fb\u5e0c\u5c11\u304c\u3093\u306e\u30ad\u30e3\u30f3\u30b5\u30fc\u30dc\u30fc\u30c9
\n\u6708\u306b\u4e00\u5ea6\u3001\u539f\u767a\u5de3\u304c\u306f\u3063\u304d\u308a\u3057\u306a\u3044\u304c\u3093\u3084\u3001\u75c7\u4f8b\u6570\u306e\u5c11\u306a\u3044\u304c\u3093\u306b\u3064\u3044\u3066\u3001\u8907\u6570\u306e\u8a3a\u7642\u79d1\u3068\u8077\u7a2e\u304c\u96c6\u307e\u3063\u3066\u6cbb\u7642\u65b9\u91dd\u3092\u76f8\u8ac7\u3059\u308b\u4f1a\u8b70\u3067\u3059\u3002\u753b\u50cf\u30fb\u75c5\u7406\u30fb\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u6240\u898b\u3092\u6301\u3061\u5bc4\u308a\u3001\u3069\u3053\u307e\u3067\u8a3a\u65ad\u3092\u8a70\u3081\u3089\u308c\u308b\u304b\u3001\u3069\u306e\u6cbb\u7642\u304c\u9078\u629e\u80a2\u306b\u306a\u308b\u304b\u3092\u9806\u306b\u78ba\u8a8d\u3057\u3066\u3044\u304d\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u6559\u79d1\u66f8\u306b\u300c\u6a19\u6e96\u6cbb\u7642\u300d\u304c\u66f8\u304b\u308c\u3066\u3044\u306a\u3044\u9818\u57df\u3067\u306f\u3001\u65b9\u91dd\u306f\u4e00\u4eba\u3067\u6c7a\u3081\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u8907\u6570\u306e\u76ee\u3067\u7d44\u307f\u7acb\u3066\u308b\u3082\u306e\u306b\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u7d44\u307f\u7acb\u3066\u65b9\u305d\u306e\u3082\u306e\u304c\u3001\u3053\u306e\u4f1a\u8b70\u3067\u5b66\u3079\u308b\u3053\u3068\u3067\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642 \u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\u306e\u4e0b\u8aad\u307f\uff08\u30d7\u30ecEP\uff09
\n\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u7d50\u679c\u3092\u6b63\u5f0f\u306b\u691c\u8a0e\u3059\u308b\u4f1a\u8b70\uff08\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\uff09\u306e\u524d\u306b\u3001\u63d0\u51fa\u3055\u308c\u305f\u75c7\u4f8b\u306e\u30ec\u30dd\u30fc\u30c8\u3092\u3042\u3089\u304b\u3058\u3081\u8aad\u307f\u8fbc\u3093\u3067\u304a\u304f\u4f5c\u696d\u3067\u3059\u3002\u4ed6\u65bd\u8a2d\u3068\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u3064\u306a\u3044\u3067\u9694\u9031\u3067\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u691c\u51fa\u3055\u308c\u305f\u907a\u4f1d\u5b50\u306e\u5909\u5316\u306b\u6cbb\u7642\u4e0a\u306e\u610f\u5473\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u305d\u306e\u5834\u306e\u8b70\u8ad6\u3067\u6025\u306b\u6c7a\u307e\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u4e0b\u8aad\u307f\u3067\u8ad6\u70b9\u3092\u6574\u7406\u3057\u3066\u304a\u304f\u6bb5\u53d6\u308a\u307e\u3067\u542b\u3081\u3066\u3001\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u306e\u5b9f\u52d9\u3067\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u533b\u5b66\u751f\u306e\u7814\u7a76\u6307\u5c0e \u2015 \u5b66\u4f1a\u6f14\u984c\u3068\u8ad6\u6587\u306e\u6e96\u5099
\n\u4eca\u9031\u306f\u5b66\u751f\u306e\u7814\u7a76\u6307\u5c0e\u304c\u91cd\u306a\u308a\u307e\u3057\u305f\u3002\u6765\u6625\u306e\u5b66\u4f1a\u306b\u75c7\u4f8b\u5831\u544a\u3092\u51fa\u3059\u305f\u3081\u306e\u6253\u3061\u5408\u308f\u305b\u3092\u884c\u3044\u3001\u307e\u305a\u8aad\u3093\u3067\u304a\u304f\u3068\u3088\u3044\u8ad6\u6587\u3092\u307e\u3068\u3081\u3066\u6e21\u3057\u307e\u3057\u305f\u3002\u5225\u306e\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30a2\u30f3\u30b1\u30fc\u30c8\u8abf\u67fb\u3092\u307e\u3068\u3081\u305f\u8ad6\u6587\u306e\u539f\u7a3f\u3092\u691c\u8a0e\u3057\u3001\u6570\u5024\u306e\u51fa\u3069\u3053\u308d\u306e\u78ba\u8a8d\u3084\u3001\u6295\u7a3f\u898f\u5b9a\u306b\u5408\u308f\u305b\u305f\u69cb\u6210\u306e\u898b\u76f4\u3057\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u5b66\u4f1a\u767a\u8868\u3084\u8ad6\u6587\u6295\u7a3f\u306f\u3001\u5927\u5b66\u9662\u306b\u5165\u3063\u3066\u304b\u3089\u59cb\u3081\u308b\u3082\u306e\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002\u6307\u5c0e\u8005\u3068\u5b66\u751f\u304c\u540c\u3058\u8868\u3092\u898b\u306a\u304c\u3089\u6570\u5b57\u3092\u7a81\u304d\u5408\u308f\u305b\u308b\u3001\u305d\u3046\u3044\u3046\u5730\u5473\u306a\u4f5c\u696d\u306e\u7a4d\u307f\u91cd\u306d\u304c\u7814\u7a76\u3067\u3059\u3002\u5f53\u79d1\u3067\u306f\u5b66\u751f\u306e\u3046\u3061\u304b\u3089\u95a2\u308f\u3063\u3066\u3082\u3089\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u521d\u671f\u81e8\u5e8a\u7814\u4fee\u533b\u306e\u63a1\u7528\u8a66\u9a13\uff08\u9762\u63a5\u5be9\u67fb\u54e1\uff09
\n\u6765\u5e74\u5ea6\u306e\u521d\u671f\u81e8\u5e8a\u7814\u4fee\u533b\u306e\u63a1\u7528\u8a66\u9a13\u306b\u3001\u5f53\u79d1\u304b\u3089\u3082\u9762\u63a5\u5be9\u67fb\u54e1\u3068\u3057\u3066\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u9762\u63a5\u306f2\u4eba1\u7d44\u3067\u62c5\u5f53\u3057\u3001\u6c7a\u3081\u3089\u308c\u305f\u8a55\u4fa1\u7968\u306b\u305d\u3063\u3066\u9032\u3081\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u8a55\u4fa1\u3059\u308b\u5074\u306b\u56de\u308b\u3068\u3001\u9762\u63a5\u3067\u898b\u3089\u308c\u3066\u3044\u308b\u306e\u304c\u300c\u3046\u307e\u304f\u8a71\u305b\u308b\u304b\u300d\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u3088\u304f\u5206\u304b\u308a\u307e\u3059\u3002\u5fd7\u671b\u306e\u7406\u7531\u3084\u3001\u3053\u308c\u307e\u3067\u306e\u7d4c\u9a13\u3092\u3069\u3046\u81ea\u5206\u306e\u8a00\u8449\u3067\u8aac\u660e\u3067\u304d\u308b\u304b\u3001\u3068\u3044\u3046\u70b9\u306b\u8a55\u4fa1\u306e\u8ef8\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u8840\u6db2\u3067\u8abf\u3079\u308b\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\uff08\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\uff09\u306e\u8aac\u660e\u4f1a
\n\u7d44\u7e54\u691c\u4f53\u3067\u306f\u306a\u304f\u8840\u6db2\u304b\u3089\u907a\u4f1d\u5b50\u306e\u5909\u5316\u3092\u8abf\u3079\u308b\u691c\u67fb\u306b\u3064\u3044\u3066\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u306e\u88fd\u54c1\u8aac\u660e\u4f1a\u306b\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u691c\u67fb\u3067\u3069\u306e\u907a\u4f1d\u5b50\u5909\u5316\u307e\u3067\u5206\u304b\u308b\u304b\u3001\u85ac\u306e\u9078\u629e\u306b\u76f4\u7d50\u3059\u308b\u9805\u76ee\uff08\u30b3\u30f3\u30d1\u30cb\u30aa\u30f3\u8a3a\u65ad\uff09\u3068\u3057\u3066\u4f55\u304c\u4f7f\u3048\u308b\u304b\u3092\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u7d44\u7e54\u3092\u63a1\u308b\u306e\u304c\u96e3\u3057\u3044\u60a3\u8005\u3055\u3093\u306b\u3082\u691c\u67fb\u306e\u9053\u304c\u958b\u3051\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u65e5\u3005\u306e\u8a3a\u7642\u3067\u3057\u3070\u3057\u3070\u554f\u984c\u306b\u306a\u308a\u307e\u3059\u3002\u691c\u67fb\u306e\u6027\u80fd\u3068\u9650\u754c\u3092\u77e5\u3063\u3066\u304a\u304f\u3068\u3001\u300c\u3053\u306e\u4eba\u306b\u306f\u3069\u3061\u3089\u306e\u691c\u67fb\u3092\u51fa\u3059\u304b\u300d\u3068\u3044\u3046\u5224\u65ad\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u80c3\u304c\u3093\u306e\u5468\u8853\u671f\u6cbb\u7642\u306b\u95a2\u3059\u308b\u30aa\u30f3\u30e9\u30a4\u30f3\u8b1b\u6f14\u4f1a
\n\u624b\u8853\u306e\u524d\u5f8c\u306b\u85ac\u7269\u7642\u6cd5\u3092\u3069\u3046\u7d44\u307f\u7acb\u3066\u308b\u304b\u3092\u30c6\u30fc\u30de\u306b\u3057\u305f\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u306e\u8b1b\u6f14\u4f1a\u306b\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u4ed6\u65bd\u8a2d\u306e\u4f7f\u7528\u7d4c\u9a13\u3092\u805e\u3051\u308b\u6a5f\u4f1a\u3067\u3082\u3042\u308a\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u3053\u3046\u3057\u305f\u4f1a\u306f\u3001\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u6539\u8a02\u3055\u308c\u308b\u524d\u306e\u300c\u73fe\u5834\u3067\u3069\u3046\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u304b\u300d\u3092\u77e5\u308b\u5834\u3067\u3059\u3002\u6587\u732e\u3060\u3051\u3067\u306f\u57cb\u307e\u3089\u306a\u3044\u90e8\u5206\u304c\u3001\u4ed6\u65bd\u8a2d\u306e\u7d4c\u9a13\u306e\u5171\u6709\u3067\u898b\u3048\u3066\u304f\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u203b \u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u30fb\u75c7\u4f8b\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u542b\u307f\u307e\u305b\u3093\u3002\u5f53\u79d1\u306e\u6d3b\u52d5\u3092\u4e00\u822c\u5316\u3057\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500
\n\u25a0 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\u30cb\u30e5\u30fc\u30b9<\/p>\n
<\/p>\n
\u30fb\u81b5\u304c\u3093\u306b\u5bfe\u3059\u308b RAS \u963b\u5bb3\u85ac\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u3001\u7c73\u56fdFDA\u304c\u627f\u8a8d\u3014\u7c73\u56fd\u3067\u306e\u627f\u8a8d\uff08\u56fd\u5185\u672a\u627f\u8a8d\uff09\u3015 <\/p>\n \u30fb\u4e2d\u533b\u5354\u30fb\u85ac\u4fa1\u5c02\u9580\u90e8\u4f1a\u304c\u696d\u754c\u304b\u3089\u610f\u898b\u8074\u53d6 \u2015 2027\u5e74\u5ea6\u306e\u85ac\u4fa1\u6539\u5b9a\u306b\u5411\u3051\u305f\u8b70\u8ad6\u304c\u59cb\u307e\u308a\u307e\u3057\u305f <\/p>\n \u30fb\u81b5\u304c\u3093\u306e\u4e00\u6b21\u6cbb\u7642\u3067\u3082\u3001RAS \u3092\u72d9\u3046\u85ac\u306e\u7b2c\u2162\u76f8\u8a66\u9a13\u304c\u4e26\u884c\u3057\u3066\u9032\u3093\u3067\u3044\u307e\u3059 <\/p>\n \u203b \u5bfe\u8c61\u9031\uff088\u670824\u65e5\u301c30\u65e5\uff09\u306e\u3042\u3044\u3060\u306b\u3001\u65e5\u672c\u56fd\u5185\u3067\u816b\u760d\u9818\u57df\u306e\u85ac\u304c\u65b0\u305f\u306b\u627f\u8a8d\u3055\u308c\u305f\u3001\u3042\u308b\u3044\u306f\u85ac\u4fa1\u57fa\u6e96\u306b\u53ce\u8f09\u3055\u308c\u305f\u3068\u3044\u3046\u52d5\u304d\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff08\u539a\u751f\u52b4\u50cd\u7701\u306e\u85ac\u4fa1\u57fa\u6e96\u53ce\u8f09\u54c1\u76ee\u30ea\u30b9\u30c8\u306e\u76f4\u8fd1\u306e\u66f4\u65b0\u306f8\u670813\u65e5\u53ce\u8f09\u5206\u3067\u3059\uff09\u3002<\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n \u300c\u72d9\u3048\u306a\u3044\u6a19\u7684\u300d\u3060\u3063\u305f RAS \u3092\u76f4\u63a5\u306d\u3089\u3046 \u2015 \u7b2c\u2162\u76f8 RASolute 302 \u8a66\u9a13 <\/p>\n \u30fb\u81b5\u7ba1\u817a\u304c\u3093\u3067\u306f9\u5272\u4ee5\u4e0a\u306b RAS \u7d4c\u8def\u306e\u6d3b\u6027\u5316\u5909\u7570\u304c\u3042\u308a\u3001\u3053\u308c\u304c\u75c5\u6c17\u3092\u99c6\u52d5\u3059\u308b\u4e2d\u5fc3\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u306f\u3001\u6d3b\u6027\u578b\uff08GTP \u7d50\u5408\u578b\u3001RAS(ON)\uff09\u306e\u5909\u7570\u578b\u30fb\u91ce\u751f\u578b RAS \u3092\u5e45\u5e83\u304f\u963b\u5bb3\u3059\u308b\u7d4c\u53e3\u85ac\u3067\u3059\u3002 <\/p>\n \u81e8\u5e8a\u7684\u610f\u7fa9\uff1a\u524d\u6cbb\u7642\u306e\u3042\u308b\u8ee2\u79fb\u6027\u81b5\u304c\u3093\u306e\u4e8c\u6b21\u6cbb\u7642\u306f\u3001\u3053\u308c\u307e\u3067\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u304c\u534a\u5e74\u524d\u5f8c\u3068\u3044\u3046\u53b3\u3057\u3044\u9818\u57df\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u4e2d\u592e\u5024\u304c\u500d\u306b\u306a\u3063\u305f\u3068\u3044\u3046\u7d50\u679c\u3067\u3059\u3002\u305f\u3060\u3057\u767a\u75b9\u30fb\u4e0b\u75e2\u30fb\u53e3\u5185\u708e\u3068\u3044\u3063\u305f\u4e0a\u76ae\u7cfb\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u9ad8\u3044\u983b\u5ea6\u3067\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u300c\u52b9\u304f\u304b\u3069\u3046\u304b\u300d\u3068\u540c\u3058\u304f\u3089\u3044\u300c\u7d9a\u3051\u3089\u308c\u308b\u304b\u3069\u3046\u304b\u300d\u304c\u554f\u308f\u308c\u308b\u85ac\u3067\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u4e21\u9762\u3092\u4e00\u7dd2\u306b\u8aad\u3080\u7df4\u7fd2\u306f\u3001\u3069\u306e\u85ac\u306e\u8ad6\u6587\u306b\u3082\u305d\u306e\u307e\u307e\u5fdc\u7528\u3067\u304d\u307e\u3059\u3002<\/p>\n <\/p>\n \u51fa\u5178\uff08PubMed \u53ce\u8f09\uff0fPMID: 42223072\uff09\uff1aDOI: 10.1056\/NEJMoa2605555<\/a>\uff08O’Reilly EM, et al. N Engl J Med 2026\uff09 <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n 9\/9\uff08\u6c34\uff09\u4ee4\u548c8\u5e74\u5ea6\u300c\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u7b49\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306e\u4f1a\u300d <\/p>\n <\/p>\n 9\/17\uff08\u6728\uff092026\u5e74\u5ea6 \u7b2c5\u56de \u591a\u5730\u70b9\u5408\u540c\u30e1\u30c7\u30a3\u30ab\u30eb\u30fb\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u300c\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u306e\u81e8\u5e8a\u5fdc\u7528\u300d <\/p>\n 11\/28\uff08\u571f\uff09\u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a 2026\u5e74\u5ea6 \u4e5d\u5dde\u5730\u533a\u30bb\u30df\u30ca\u30fc <\/p>\n \u5f53\u79d1\u306e\u898b\u5b66\u30fb\u5b9f\u7fd2\u30fb\u9032\u8def\u76f8\u8ac7\u306f\u968f\u6642\u53d7\u3051\u4ed8\u3051\u3066\u3044\u307e\u3059 <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n RAS \u306f\u3001\u7d30\u80de\u306e\u5897\u6b96\u306e\u30b9\u30a4\u30c3\u30c1\u306b\u3042\u305f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002GTP \u304c\u7d50\u5408\u3057\u305f\u72b6\u614b\uff08ON\uff09\u3067\u4e0b\u6d41\u306b\u5897\u6b96\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u6d41\u3057\u3001GTP \u3092\u5206\u89e3\u3057\u3066 GDP \u306b\u306a\u308b\u3068\u6b62\u307e\u308b\uff08OFF\uff09\u3002\u3053\u306e\u5207\u308a\u66ff\u3048\u304c\u3046\u307e\u304f\u3044\u304b\u306a\u304f\u306a\u308a\u3001ON \u306e\u307e\u307e\u56fa\u5b9a\u3055\u308c\u3066\u3057\u307e\u3046\u306e\u304c RAS \u5909\u7570\u306e\u304c\u3093\u3067\u3059\u3002\u81b5\u304c\u3093\u3067\u306f9\u5272\u4ee5\u4e0a\u3001\u5927\u8178\u304c\u3093\u3084\u80ba\u304c\u3093\u3067\u3082\u304b\u306a\u308a\u306e\u5272\u5408\u3067\u898b\u3064\u304b\u308a\u307e\u3059\u3002<\/p>\n \u983b\u5ea6\u304c\u3053\u308c\u3060\u3051\u9ad8\u3044\u306e\u306b\u300140\u5e74\u3082\u306e\u3042\u3044\u3060\u85ac\u306b\u306a\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u7406\u7531\u306e\u4e00\u3064\u306f\u3001RAS \u306e\u8868\u9762\u304c\u3064\u308b\u308a\u3068\u3057\u3066\u3044\u3066\u3001\u85ac\u304c\u5f15\u3063\u304b\u304b\u308b\u6df1\u3044\u304f\u307c\u307f\uff08\u30dd\u30b1\u30c3\u30c8\uff09\u304c\u898b\u5f53\u305f\u3089\u306a\u304b\u3063\u305f\u3053\u3068\u3067\u3059\u3002\u3082\u3046\u4e00\u3064\u306f\u3001RAS \u3068 GTP \u306e\u7d50\u5408\u304c\u975e\u5e38\u306b\u5f37\u304f\u3001GTP \u3068\u7af6\u4e89\u3057\u3066\u7d50\u5408\u3092\u90aa\u9b54\u3059\u308b\u3001\u3068\u3044\u3046\u901a\u5e38\u306e\u4f5c\u6226\u304c\u4f7f\u3048\u306a\u304b\u3063\u305f\u3053\u3068\u3002\u300cundruggable\uff08\u85ac\u3067\u72d9\u3048\u306a\u3044\uff09\u6a19\u7684\u300d\u3068\u547c\u3070\u308c\u3066\u304d\u305f\u3086\u3048\u3093\u3067\u3059\u3002<\/p>\n \u6700\u521d\u306e\u7a81\u7834\u53e3\u306f\u3001KRAS G12C \u3068\u3044\u3046\u7279\u5b9a\u306e\u5909\u7570\u3067\u3057\u305f\u3002\u5909\u7570\u3067\u3067\u304d\u305f\u30b7\u30b9\u30c6\u30a4\u30f3\u306b\u5171\u6709\u7d50\u5408\u3067\u304f\u3063\u3064\u304f\u85ac\u304c\u4f5c\u3089\u308c\u30012021\u5e74\u4ee5\u964d\u306b\u5b9f\u7528\u5316\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3060\u3057 G12C \u306f\u81b5\u304c\u3093\u3067\u306f\u6570%\u306b\u3068\u3069\u307e\u308a\u3001\u81b5\u304c\u3093\u306b\u591a\u3044 G12D \u3084 G12V \u306b\u306f\u4f7f\u3048\u307e\u305b\u3093\u3002<\/p>\n \u4eca\u56de\u8a71\u984c\u306b\u3057\u305f\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u306f\u3001\u5225\u306e\u8003\u3048\u65b9\u3092\u3068\u308a\u307e\u3059\u3002\u85ac\u304c\u5358\u72ec\u3067 RAS \u306b\u306f\u307e\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u7d30\u80de\u306e\u4e2d\u306b\u3042\u308b\u30b7\u30af\u30ed\u30d5\u30a3\u30ea\u30f3A \u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u5148\u306b\u8907\u5408\u4f53\u3092\u3064\u304f\u308a\u3001\u305d\u306e\u8907\u5408\u4f53\u304c ON \u72b6\u614b\u306e RAS \u306e\u8868\u9762\u306b\u65b0\u3057\u304f\u751f\u307e\u308c\u305f\u300c\u304f\u307c\u307f\u300d\u306b\u306f\u307e\u308b\u3002\u4e09\u8005\u304c\u7d44\u307f\u5408\u308f\u3055\u308b\u306e\u3067\u3001\u4e09\u91cd\u8907\u5408\u4f53\uff08tri-complex\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3053\u306e\u4ed5\u7d44\u307f\u3060\u3068\u3001\u5909\u7570\u306e\u7a2e\u985e\uff08G12D\u3001G12V\u3001Q61 \u306a\u3069\uff09\u306b\u3042\u307e\u308a\u5de6\u53f3\u3055\u308c\u305a\u306b RAS \u3092\u6b62\u3081\u3089\u308c\u308b\u3001\u3068\u3044\u3046\u306e\u304c\u300cpan-RAS\u300d\u3068\u547c\u3070\u308c\u308b\u7406\u7531\u3067\u3059\u3002<\/p>\n \u85ac\u304c\u52b9\u304b\u306a\u3044\u3068\u3055\u308c\u3066\u304d\u305f\u6a19\u7684\u304c\u3001\u5316\u5b66\u306e\u5de5\u592b\u3067\u5c04\u7a0b\u306b\u5165\u308b\u3002\u816b\u760d\u5185\u79d1\u306e\u9762\u767d\u3055\u306f\u65b0\u3057\u3044\u85ac\u306e\u540d\u524d\u3092\u899a\u3048\u308b\u3053\u3068\u3067\u306f\u306a\u304f\u3001\u3053\u3046\u3044\u3046\u300c\u306a\u305c\u4eca\u307e\u3067\u3067\u304d\u306a\u304b\u3063\u305f\u306e\u304b\u300d\u300c\u4f55\u304c\u5909\u308f\u3063\u305f\u306e\u304b\u300d\u3092\u8ffd\u3048\u308b\u3053\u3068\u306b\u3042\u308b\u3068\u601d\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u540c\u3058\u8ad6\u6587\u306b\u306f\u3001\u4e0a\u76ae\u7cfb\u306e\u6709\u5bb3\u4e8b\u8c61\u304c\u9ad8\u983b\u5ea6\u306b\u51fa\u308b\u3053\u3068\u3082\u66f8\u304b\u308c\u3066\u3044\u307e\u3059\u3002\u52b9\u304d\u76ee\u3068\u526f\u4f5c\u7528\u3092\u4e26\u3079\u3066\u8aad\u3080\u7fd2\u6163\u306f\u3001\u65e9\u3044\u3046\u3061\u306b\u8eab\u306b\u3064\u3051\u3066\u304a\u3044\u3066\u640d\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e748\u6708\u7b2c4\u9031\uff0f8\u670824\u65e5\u301c8\u670830\u65e5\uff09 \u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1 \u816b\u760d\u5185\u79d1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u65b9\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u306e\u6d3b\u52d5\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u4e16\u306e\u4e2d\u306e\u52d5\u304d\uff08\u8ad6\u6587\u30fb\u5b66\u4f1a […]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"class_list":["post-2684","post","type-post","status-publish","format-standard","hentry","category-thisweeksoncology"],"publishpress_future_action":{"enabled":false,"date":"2026-09-08 16:01:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2684"}],"version-history":[{"count":11,"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2684\/revisions"}],"predecessor-version":[{"id":2695,"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/2684\/revisions\/2695"}],"wp:attachment":[{"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/oncoc.showa.gunma-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n2026\u5e748\u670826\u65e5\u3001\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u304c\u3001\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\uff08daraxonrasib\u3001\u88fd\u54c1\u540d RASONQUE\u3001Revolution Medicines \u793e\uff09\u3092\u3001\u8ee2\u79fb\u6027\u81b5\u817a\u304c\u3093\u306e\u6210\u4eba\uff08\u5168\u8eab\u7642\u6cd5\u30921\u30ec\u30b8\u30e1\u30f3\u4ee5\u4e0a\u53d7\u3051\u305f\u65b9\u3001\u307e\u305f\u306f\u591a\u5264\u4f75\u7528\u306e\u5168\u8eab\u7642\u6cd5\u306e\u9069\u5fdc\u3068\u306a\u3089\u306a\u3044\u65b9\uff09\u306b\u5bfe\u3057\u3066\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002RAS \u306e GTPase \u30d5\u30a1\u30df\u30ea\u30fc\u3092\u963b\u5bb3\u3059\u308b\u7d4c\u53e3\u85ac\u3067\u3001\u7528\u91cf\u306f300mg\u30921\u65e51\u56de\u3001\u75c5\u52e2\u9032\u884c\u307e\u305f\u306f\u5fcd\u5bb9\u3067\u304d\u306a\u3044\u6bd2\u6027\u304c\u73fe\u308c\u308b\u307e\u3067\u6295\u4e0e\u3059\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6839\u62e0\u3068\u306a\u3063\u305f\u306e\u306f\u3001500\u4f8b\u30921\u5bfe1\u306b\u5272\u308a\u4ed8\u3051\u305f\u7121\u4f5c\u70ba\u5316\u975e\u76f2\u691c\u8a66\u9a13 RASolute 302\uff08NCT06625320\uff09\u3067\u3059\uff08\u7d50\u679c\u306f\u4e0b\u306e\u300c\u4eca\u9031\u306e\u4e00\u5831\u300d\u3067\u7d39\u4ecb\u3057\u307e\u3059\uff09\u3002
\n\u6bb5\u968e\u306b\u3054\u6ce8\u610f\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306f\u7c73\u56fd\u3067\u306e\u627f\u8a8d\u3067\u3042\u308a\u3001\u65e5\u672c\u3067\u306e\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u30fb\u85ac\u4fa1\u57fa\u6e96\u53ce\u8f09\u306f\u3001\u3053\u306e\u8a18\u4e8b\u306e\u4f5c\u6210\u6642\u70b9\u3067\u306f\u884c\u308f\u308c\u3066\u3044\u307e\u305b\u3093\uff08\u56fd\u5185\u3067\u306e\u8ca9\u58f2\u540d\u3082\u6c7a\u307e\u3063\u3066\u3044\u307e\u305b\u3093\uff09\u3002\u65e5\u672c\u3067\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u307e\u3067\u306b\u306f\u3001\u56fd\u5185\u3067\u306e\u7533\u8acb\u30fb\u5be9\u67fb\u30fb\u627f\u8a8d\u30fb\u85ac\u4fa1\u53ce\u8f09\u3068\u3044\u3046\u624b\u7d9a\u304d\u304c\u5225\u306b\u5fc5\u8981\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u81b5\u304c\u3093\u3067\u306f9\u5272\u4ee5\u4e0a\u306e\u75c7\u4f8b\u306b KRAS \u306e\u5909\u7570\u304c\u3042\u308b\u3068\u77e5\u3089\u308c\u306a\u304c\u3089\u3001\u9577\u3044\u3042\u3044\u3060\u300c\u85ac\u3067\u72d9\u3048\u306a\u3044\u6a19\u7684\u300d\u3068\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u306e\u524d\u63d0\u304c\u5909\u308f\u3063\u305f\u3068\u3044\u3046\u610f\u5473\u3067\u3001\u6559\u79d1\u66f8\u306e\u8a18\u8ff0\u304c\u66f8\u304d\u63db\u308f\u308b\u7a2e\u985e\u306e\u30cb\u30e5\u30fc\u30b9\u3067\u3059\u3002\u6d77\u5916\u306e\u627f\u8a8d\u304c\u65e5\u672c\u306b\u5c4a\u304f\u307e\u3067\u306b\u306f\u6642\u9593\u5dee\u304c\u3042\u308a\u3001\u305d\u306e\u6642\u9593\u5dee\u3053\u305d\u304c\u65e5\u5e38\u7684\u306a\u8a71\u984c\u306b\u306a\u308b\u3001\u3068\u3044\u3046\u70b9\u3082\u542b\u3081\u3066\u77e5\u3063\u3066\u304a\u304f\u3068\u3088\u3044\u3068\u601d\u3044\u307e\u3059\u3002
\n\u51fa\u5178\uff1aU.S. Food and Drug Administration\u300cFDA approves daraxonrasib for metastatic pancreatic adenocarcinoma\u300d<\/a> \uff0f FDA \u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9 <\/a><\/p>\n
\n2026\u5e748\u670826\u65e5\u3001\u4e2d\u592e\u793e\u4f1a\u4fdd\u967a\u533b\u7642\u5354\u8b70\u4f1a\uff08\u4e2d\u533b\u5354\uff09\u306e\u85ac\u4fa1\u5c02\u9580\u90e8\u4f1a \u7b2c248\u56de\u304c\u958b\u304b\u308c\u3001\u300c\u95a2\u4fc2\u696d\u754c\u304b\u3089\u306e\u610f\u898b\u8074\u53d6\u306b\u3064\u3044\u3066\u300d\u304c\u8b70\u984c\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u65e5\u672c\u88fd\u85ac\u56e3\u4f53\u9023\u5408\u4f1a\u3001\u65e5\u672c\u88fd\u85ac\u5de5\u696d\u5354\u4f1a\u30fb\u7c73\u56fd\u7814\u7a76\u88fd\u85ac\u5de5\u696d\u5354\u4f1a\u30fb\u6b27\u5dde\u88fd\u85ac\u56e3\u4f53\u9023\u5408\u4f1a\u3001\u65e5\u672c\u30b8\u30a7\u30cd\u30ea\u30c3\u30af\u88fd\u85ac\u5354\u4f1a\u3001\u65e5\u672c\u533b\u85ac\u54c1\u5378\u58f2\u696d\u9023\u5408\u4f1a\u304c\u610f\u898b\u3092\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002\u85ac\u4fa1\u306f2\u5e74\u306b\u4e00\u5ea6\u306e\u6539\u5b9a\u306e\u3042\u3044\u3060\u306e\u5e74\u306b\u3082\u898b\u76f4\u3055\u308c\u308b\u4ed5\u7d44\u307f\uff08\u4e2d\u9593\u5e74\u6539\u5b9a\uff09\u304c\u3042\u308a\u3001\u305d\u306e\u5bfe\u8c61\u7bc4\u56f2\u3084\u30eb\u30fc\u30eb\u3092\u3069\u3046\u3059\u308b\u304b\u304c\u4eca\u5f8c\u306e\u8ad6\u70b9\u306b\u306a\u308a\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u85ac\u306e\u5024\u6bb5\u306f\u3001\u4f01\u696d\u304c\u6c7a\u3081\u3066\u3044\u308b\u308f\u3051\u3067\u3082\u3001\u75c5\u9662\u304c\u6c7a\u3081\u3066\u3044\u308b\u308f\u3051\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u56fd\u306e\u4f1a\u8b70\u3067\u8b70\u8ad6\u3057\u3066\u6c7a\u307e\u308b\u516c\u5b9a\u4fa1\u683c\u3067\u3059\u3002\u304c\u3093\u85ac\u7269\u7642\u6cd5\u306f\u9ad8\u984d\u306a\u85ac\u304c\u591a\u304f\u3001\u3053\u306e\u8b70\u8ad6\u306e\u884c\u65b9\u306f\u3001\u79c1\u305f\u3061\u304c\u65e5\u3005\u3069\u306e\u85ac\u3092\u4f7f\u3048\u308b\u304b\u3068\u3044\u3046\u8a71\u3068\u5730\u7d9a\u304d\u3067\u3059\u3002\u8cc7\u6599\u306f\u3059\u3079\u3066\u516c\u958b\u3055\u308c\u3066\u3044\u308b\u306e\u3067\u3001\u4e00\u5ea6\u306e\u305e\u3044\u3066\u307f\u308b\u3068\u533b\u7642\u5236\u5ea6\u306e\u898b\u3048\u65b9\u304c\u5909\u308f\u308a\u307e\u3059\u3002
\n\u51fa\u5178\uff1a\u539a\u751f\u52b4\u50cd\u7701\u300c\u4e2d\u592e\u793e\u4f1a\u4fdd\u967a\u533b\u7642\u5354\u8b70\u4f1a \u85ac\u4fa1\u5c02\u9580\u90e8\u4f1a\uff08\u7b2c248\u56de\uff09\u8b70\u4e8b\u6b21\u7b2c\u300d\uff08\u4ee4\u548c8\u5e748\u670826\u65e5\u958b\u50ac\uff09 <\/a><\/p>\n
\n\u4eca\u56de\u306e\u627f\u8a8d\u306f\u300c\u4e8c\u6b21\u6cbb\u7642\u4ee5\u964d\u300d\u304c\u5bfe\u8c61\u3067\u3059\u304c\u3001\u672a\u6cbb\u7642\u306e\u8ee2\u79fb\u6027\u81b5\u304c\u3093\u3092\u5bfe\u8c61\u306b\u3057\u305f\u7b2c\u2162\u76f8\u8a66\u9a13\u3082\u8907\u6570\u52d5\u3044\u3066\u3044\u307e\u3059\u30028\u670828\u65e5\u306b\u516c\u8868\u3055\u308c\u305f\u7dcf\u8aac\u3067\u306f\u3001pan-RAS \u963b\u5bb3\u85ac\u306e\u307b\u304b\u3001KRAS G12D \u306b\u9078\u629e\u7684\u306a\u85ac\u3001MEK \u963b\u5bb3\u85ac\u3001\u5206\u89e3\u85ac\uff08\u30c7\u30b0\u30ec\u30fc\u30c0\u30fc\uff09\u306a\u3069\u3001\u4f5c\u7528\u306e\u7570\u306a\u308b\u8907\u6570\u306e\u85ac\u5264\u304c\u4e00\u6b21\u6cbb\u7642\u3067\u8a55\u4fa1\u3055\u308c\u3066\u3044\u308b\u72b6\u6cc1\u304c\u6574\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u591a\u304f\u306f\u5316\u5b66\u7642\u6cd5\u3068\u306e\u4f75\u7528\u3068\u5316\u5b66\u7642\u6cd5\u5358\u72ec\u306e\u6bd4\u8f03\u3067\u3059\u304c\u3001\u85ac\u5264\u5358\u72ec\u306e\u7fa4\u3092\u7f6e\u3044\u305f\u8a66\u9a13\u3082\u3042\u308a\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u4e00\u3064\u306e\u85ac\u304c\u627f\u8a8d\u3055\u308c\u308b\u3068\u3001\u6b21\u306f\u300c\u3069\u306e\u9806\u756a\u3067\u4f7f\u3046\u304b\u300d\u300c\u4e00\u6b21\u6cbb\u7642\u306b\u6301\u3063\u3066\u3053\u3089\u308c\u308b\u304b\u300d\u304c\u8ad6\u70b9\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u79fb\u308a\u5909\u308f\u308a\u306e\u901f\u3055\u306f\u3001\u816b\u760d\u5185\u79d1\u3068\u3044\u3046\u9818\u57df\u306e\u6027\u683c\u3092\u3088\u304f\u8868\u3057\u3066\u3044\u307e\u3059\u3002
\n\u51fa\u5178\uff08PubMed \u53ce\u8f09\uff0fPMID: 42663603\uff09\uff1aDempke WCM, et al. Future Oncol. 2026 Aug 28\uff08\u30aa\u30f3\u30e9\u30a4\u30f3\u5148\u884c\uff09. DOI: 10.1080\/14796694.2026.2725499 <\/a><\/p>\n
\n\u25a0 \u4eca\u9031\u306e\u4e00\u5831\uff08\u6ce8\u76ee\u8ad6\u6587\uff09\u3014\u81b5\u304c\u3093\uff0f\u5206\u5b50\u6a19\u7684\u6cbb\u7642\u3015<\/p>\n
\nN Engl J Med. 2026;395(4):325\u2013337.\uff0f\u7b2c\u2162\u76f8\u30fb\u56fd\u969b\u5171\u540c\u30fb\u975e\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\uff08RASolute 302\u3001ClinicalTrials.gov NCT06625320\uff09<\/p>\n
\n\u30fb\u5316\u5b66\u7642\u6cd5\u306b\u3088\u308b\u524d\u6cbb\u7642\u3092\u53d7\u3051\u305f\u8ee2\u79fb\u6027\u81b5\u7ba1\u817a\u304c\u3093\u306e\u60a3\u8005\u3055\u3093\u3092\u3001\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u7fa4\u3068\u4e3b\u6cbb\u533b\u9078\u629e\u306e\u5316\u5b66\u7642\u6cd5\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u307e\u3057\u305f\u3002\u767b\u9332\u306f500\u4f8b\uff08\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u7fa4248\u4f8b\u3001\u5316\u5b66\u7642\u6cd5\u7fa4252\u4f8b\uff09\u3067\u3001\u305d\u306e\u3046\u306191.8%\u304c G12 \u5909\u7570\u3092\u6709\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306f\u3001G12 \u5909\u7570\u4f8b\u306b\u304a\u3051\u308b\u5168\u751f\u5b58\u671f\u9593\u3068\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e2\u3064\u3067\u3059\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002
\n\u30fb\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001G12 \u96c6\u56e3\u3067\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u7fa413.2\u304b\u6708\u30fb\u5316\u5b66\u7642\u6cd5\u7fa46.6\u304b\u6708\u3001\u5168\u4f53\u96c6\u56e3\u306713.2\u304b\u6708\u30fb6.7\u304b\u6708\u3002\u30cf\u30b6\u30fc\u30c9\u6bd4\u306f\u3044\u305a\u308c\u30820.40\uff08P<0.001\uff09\u3067\u3057\u305f\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001G12 \u96c6\u56e3\u30677.3\u304b\u6708\u30fb3.5\u304b\u6708\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.45\uff09\u3001\u5168\u4f53\u96c6\u56e3\u30677.2\u304b\u6708\u30fb3.6\u304b\u6708\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.49\uff09\u3067\u3001\u3044\u305a\u308c\u3082 P<0.001 \u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002
\n\u30fb\u6cbb\u7642\u958b\u59cb\u5f8c\u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u30c0\u30e9\u30af\u30bd\u30f3\u30e9\u30b7\u30d6\u7fa4\u306e\u5168\u4f8b\u3001\u5316\u5b66\u7642\u6cd5\u7fa4\u306e97.7%\u3067\u5831\u544a\u3055\u308c\u3001Grade 3 \u4ee5\u4e0a\u306f\u305d\u308c\u305e\u308c61.8%\u300169.6%\u3002\u6cbb\u7642\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u6cbb\u7642\u4e2d\u6b62\u306f1.2%\u5bfe11.2%\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002\u8457\u8005\u306b\u306f\u65e5\u672c\u306e\u65bd\u8a2d\uff08\u795e\u5948\u5ddd\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff09\u3082\u540d\u3092\u9023\u306d\u3066\u3044\u307e\u3059\u3002<\/p>\n
\n\u4f5c\u7528\u6a5f\u5e8f\u3068\u8010\u6027\u306e\u7dcf\u8aac\uff08\u65e5\u672c\u304b\u3089\u306e\u5831\u544a\uff09\uff1aDOI: 10.1111\/cas.70497<\/a>\uff08Honda R. Cancer Sci 2026\uff0fPMID: 42557936\uff09<\/p>\n
\n\u25a0 \u5b66\u4f1a\u30fb\u30bb\u30df\u30ca\u30fc\uff0f\u884c\u4e8b<\/p>\n
\n\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u7b49\u3092\u5bfe\u8c61\u306b\u3001\u5c06\u6765\u306e\u30ad\u30e3\u30ea\u30a2\u5f62\u6210\u3084\u5730\u57df\u533b\u7642\u3078\u306e\u7406\u89e3\u3092\u6df1\u3081\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u3066\u958b\u304b\u308c\u308b\u4f1a\u3067\u3059\u3002
\n\u30fb\u65e5\u6642\uff1a2026\u5e749\u67089\u65e5\uff08\u6c34\uff0913:30\u301c14:50
\n\u30fb\u4f1a\u5834\uff1a\u7fa4\u99ac\u5927\u5b66\u662d\u548c\u30ad\u30e3\u30f3\u30d1\u30b9 \u533b\u5b66\u79d1 \u81e8\u5e8a\u5927\u8b1b\u5802
\n\u30fb\u4e3b\u50ac\uff1a\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u5730\u57df\u533b\u7642\u7814\u7a76\u30fb\u6559\u80b2\u30bb\u30f3\u30bf\u30fc\uff08\u662d\u548c\u5730\u533a\u4e8b\u52d9\u90e8 \u7dcf\u52d9\u8ab2 \u5730\u57df\u533b\u7642\u652f\u63f4\u4fc2\uff09
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u7fa4\u99ac\u3067\u50cd\u304f\u3068\u3044\u3046\u9032\u8def\u3092\u3001\u5236\u5ea6\u3084\u652f\u63f4\u306e\u8a71\u3068\u3042\u308f\u305b\u3066\u5177\u4f53\u7684\u306b\u8003\u3048\u3089\u308c\u308b\u6a5f\u4f1a\u3067\u3059\u3002<\/p>\n
\n\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u304c\u3001\u304c\u3093\u8a3a\u7642\u9023\u643a\u62e0\u70b9\u75c5\u9662\u7b49\u306e\u533b\u7642\u5f93\u4e8b\u8005\u5411\u3051\u306b\u958b\u3044\u3066\u3044\u308b\u30aa\u30f3\u30e9\u30a4\u30f3\u306e\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u3067\u3059\u3002\u4eca\u56de\u306e\u30c6\u30fc\u30de\u306f\u3001\u4eca\u9031\u5f53\u79d1\u3067\u3082\u8a71\u984c\u306b\u306a\u3063\u305f\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u3002\u53c2\u52a0\u306f\u7121\u6599\u3067\u3001Zoom \u306e\u4e8b\u524d\u767b\u9332\u304c\u5fc5\u8981\u3067\u3059\u3002
\n\u30fb\u6f14\u984c\uff1a\u2460\u5f53\u30bb\u30f3\u30bf\u30fc\u3067\u306e\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u7814\u7a76\u3000\u2461\u80c6\u9053\u7cfb\u816b\u760d\u306b\u5bfe\u3059\u308b\u80c6\u6c41\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u3000\u2462\u793e\u4f1a\u5b9f\u88c5\u3092\u76ee\u6307\u3057\u305f\u8d85\u9ad8\u611f\u5ea6ctDNA\u6642\u7cfb\u5217\u30e2\u30cb\u30bf\u30ea\u30f3\u30b0
\n\u30fb\u6f14\u8005\uff1a\u2460\u5b89\u7530 \u7d14 \u5148\u751f\uff08\u5bae\u57ce\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc \u7814\u7a76\u6240\u9577\uff09\u3000\u2461\u9752\u6728 \u4fee\u4e00 \u5148\u751f\uff08\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662 \u6d88\u5316\u5668\u5916\u79d1\u5b66\u5206\u91ce \u51c6\u6559\u6388\uff09\u3000\u2462\u897f\u585a \u54f2 \u5148\u751f\uff08\u5ca9\u624b\u533b\u79d1\u5927\u5b66\u533b\u6b6f\u85ac\u7dcf\u5408\u7814\u7a76\u6240 \u5275\u85ac\u30fb\u533b\u7642\u958b\u767a\u90e8\u9580 \u7279\u4efb\u6559\u6388\uff09
\n\u30fb\u53f8\u4f1a\uff1a\u5b89\u7530 \u7d14 \u5148\u751f\uff08\u5bae\u57ce\u770c\u7acb\u304c\u3093\u30bb\u30f3\u30bf\u30fc \u7814\u7a76\u6240\u9577\uff09
\n\u30fb\u65e5\u6642\uff1a2026\u5e749\u670817\u65e5\uff08\u6728\uff0917:30\u301c18:30
\n\u30fb\u4f1a\u5834\uff1aZoom \u306b\u3088\u308b\u30aa\u30f3\u30e9\u30a4\u30f3\u958b\u50ac
\n\u30fb\u4e3b\u50ac\uff1a\u56fd\u7acb\u304c\u3093\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u304c\u3093\u5bfe\u7b56\u7814\u7a76\u6240 \u304c\u3093\u533b\u7642\u652f\u63f4\u90e8\uff08\u533b\u7642\u5f93\u4e8b\u8005\u5411\u3051\u30fb\u53c2\u52a0\u7121\u6599\u30fbZoom \u4e8b\u524d\u767b\u9332\u304c\u5fc5\u8981\uff09
\n\u30fb\u767b\u9332\uff1ahttps:\/\/www.google.com\/url?q=https:\/\/zoom.us\/meeting\/register\/B92_Gc4_RxShQ6eEFi6S2g&source=gmail&ust=1788299235008000&sa=E<\/a> \uff08\u65e5\u672c\u304c\u3093\u6cbb\u7642\u8a8d\u5b9a\u533b\u6a5f\u69cb\u306e\u5358\u4f4d\u5bfe\u8c61\u30d7\u30ed\u30b0\u30e9\u30e0\u3002\u5358\u4f4d\u53d6\u5f97\u3092\u5e0c\u671b\u3059\u308b\u5834\u5408\u306e\u767b\u9332\u7de0\u5207\u306f9\u670816\u65e516:00\uff09
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u8840\u6db2\u3084\u80c6\u6c41\u304b\u3089\u907a\u4f1d\u5b50\u306e\u60c5\u5831\u3092\u8aad\u3080\u6280\u8853\u304c\u3001\u7814\u7a76\u5ba4\u306e\u8a71\u304b\u3089\u8a3a\u7642\u306e\u8a71\u306b\u79fb\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u30023\u6f14\u984c\u3068\u3082\u5b9f\u969b\u306b\u624b\u3092\u52d5\u304b\u3057\u3066\u3044\u308b\u65bd\u8a2d\u304b\u3089\u306e\u5831\u544a\u3067\u30011\u6642\u9593\u3067\u5168\u4f53\u50cf\u304c\u3064\u304b\u3081\u307e\u3059\u3002<\/p>\n
\n\u5b8c\u5168WEB\u958b\u50ac\u306e\u305f\u3081\u3001\u4e5d\u5dde\u5730\u533a\u4ee5\u5916\u304b\u3089\u3082\u53c2\u52a0\u3067\u304d\u307e\u3059\u3002\u5b66\u4f1a\u306e\u4f1a\u54e1\u3067\u306a\u304f\u3066\u3082\u53c2\u52a0\u3067\u304d\u3001\u53c2\u52a0\u8cbb\u306f\u7121\u6599\u3002\u6848\u5185\u6587\u306b\u306f\u3001\u3053\u308c\u304b\u3089\u5c02\u9580\u533b\u3092\u76ee\u6307\u3059\u533b\u5e2b\u306e\u307b\u304b\u3001\u7814\u4fee\u533b\u3084\u30b3\u30e1\u30c7\u30a3\u30ab\u30eb\u30b9\u30bf\u30c3\u30d5\u306e\u53c2\u52a0\u3082\u6b53\u8fce\u3059\u308b\u65e8\u304c\u8a18\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u30fb\u65e5\u6642\uff1a2026\u5e7411\u670828\u65e5\uff08\u571f\uff0913:30\u301c16:20
\n\u30fb\u4f1a\u5834\uff1a\u5b8c\u5168WEB\u958b\u50ac
\n\u30fb\u5bfe\u8c61\uff1a\u304c\u3093\u85ac\u7269\u7642\u6cd5\u5c02\u9580\u533b\u3001\u5c02\u9580\u533b\u3092\u76ee\u6307\u3059\u533b\u5e2b\u3001\u770b\u8b77\u5e2b\u30fb\u85ac\u5264\u5e2b\u306a\u3069\u306e\u533b\u7642\u5f93\u4e8b\u8005\uff08JSMO\u4f1a\u54e1\u8cc7\u683c\u306f\u4e0d\u554f\u30fb\u53c2\u52a0\u8cbb\u7121\u6599\uff09
\n\u30fb\u4e3b\u50ac\uff1a\u516c\u76ca\u793e\u56e3\u6cd5\u4eba \u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\uff08\u4e8b\u524d\u306e\u53c2\u52a0\u767b\u9332\u304c\u5fc5\u8981\uff09
\n\u30fb\u6848\u5185\uff1a\u30d7\u30ed\u30b0\u30e9\u30e0\uff08PDF\uff09<\/a>\uff0f \u53c2\u52a0\u767b\u9332\u30d5\u30a9\u30fc\u30e0\u00a0<\/a>
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u5c02\u9580\u533b\u3092\u76ee\u6307\u3059\u4eba\u5411\u3051\u306e\u5185\u5bb9\u304c\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u7121\u6599\u3067\u8074\u3051\u307e\u3059\u3002\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u3046\u3061\u306b\u4e00\u5ea6\u3053\u3046\u3044\u3046\u4f1a\u3092\u306e\u305e\u3044\u3066\u304a\u304f\u3068\u3001\u5c02\u9580\u533b\u5236\u5ea6\u304c\u5177\u4f53\u7684\u306a\u3082\u306e\u3068\u3057\u3066\u898b\u3048\u3066\u304d\u307e\u3059\u3002<\/p>\n
\n\u5916\u6765\u3084\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u306e\u898b\u5b66\u3001\u77ed\u671f\u306e\u5b9f\u7fd2\u306a\u3069\u3001\u5e0c\u671b\u306b\u5fdc\u3058\u3066\u65e5\u7a0b\u3092\u8abf\u6574\u3057\u307e\u3059\u3002\u5b66\u5e74\u3084\u6240\u5c5e\u306f\u554f\u3044\u307e\u305b\u3093\u3002\u304a\u554f\u3044\u5408\u308f\u305b\u306f\u816b\u760d\u5185\u79d1\u307e\u3067\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u3053\u306e\u8a18\u4e8b\u3067\u7d39\u4ecb\u3057\u3066\u3044\u308b\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u3084\u691c\u8a0e\u4f1a\u306f\u3001\u5b9f\u969b\u306b\u898b\u306b\u6765\u3066\u3044\u305f\u3060\u3051\u307e\u3059\u3002<\/p>\n
\n\u25a0 \u3072\u3068\u3053\u3068\u30b3\u30e9\u30e0 \u2015 RAS \u306f\u306a\u305c\u300c\u72d9\u3048\u306a\u3044\u6a19\u7684\u300d\u3068\u547c\u3070\u308c\u3066\u304d\u305f\u304b<\/p>\n
\n\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1\uff0f2026-09-01 \u4f5c\u6210
\n\u203b \u63b2\u8f09\u5185\u5bb9\u30fb\u51fa\u5178\u306f\u4f5c\u6210\u6642\u70b9\u306e\u60c5\u5831\u306b\u57fa\u3065\u304d\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"