\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e748\u6708\u7b2c2\u9031\uff0f8\u670810\u65e5\u301c8\u670816\u65e5\uff09
\n\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1<\/p>\n
<\/p>\n
\u816b\u760d\u5185\u79d1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u65b9\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u306e\u6d3b\u52d5\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u4e16\u306e\u4e2d\u306e\u52d5\u304d\uff08\u8ad6\u6587\u30fb\u5b66\u4f1a\u30fb\u5236\u5ea6\uff09\u3092\u3001\u6bce\u9031\u307e\u3068\u3081\u3066\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002<\/p>\n
\u4eca\u9031\u306f\u304a\u76c6\u306e\u9031\u3067\u3001\u5b9a\u4f8b\u306e\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u306e\u591a\u304f\u306f\u4f11\u307f\u3067\u3057\u305f\u3002\u305d\u306e\u3076\u3093\u3001\u5927\u8178\u304c\u3093\u306e\u300c\u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\u300d\u3068\u3044\u3046\u8a71\u984c\u3092\u5c11\u3057\u4e01\u5be7\u306b\u898b\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n
\u25a0 \u4eca\u9031\u306e\u5f53\u79d1\u304b\u3089<\/p>\n
<\/p>\n
\u30fb\u304a\u76c6\u671f\u9593\u306e\u8a3a\u7642\u4f53\u5236
\n\u4eca\u9031\u306f\u591a\u304f\u306e\u5b9a\u4f8b\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u304c\u4f11\u307f\u3067\u3057\u305f\u3002\u4e00\u65b9\u3067\u3001\u5916\u6765\u3068\u70b9\u6ef4\u6cbb\u7642\u306f\u66a6\u3069\u304a\u308a\u306b\u7d9a\u304d\u307e\u3059\u3002\u6297\u304c\u3093\u5264\u306b\u306f\u6295\u4e0e\u9593\u9694\u304c\u6c7a\u307e\u3063\u3066\u3044\u308b\u3082\u306e\u304c\u591a\u304f\u3001\u4f11\u307f\u3060\u304b\u3089\u3068\u3044\u3063\u3066\u5f8c\u308d\u306b\u305a\u3089\u305b\u308b\u3068\u306f\u9650\u3089\u306a\u3044\u305f\u3081\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u304c\u3093\u85ac\u7269\u7642\u6cd5\u306b\u306f\u300c\u4e88\u5b9a\u3069\u304a\u308a\u306b\u7d9a\u3051\u308b\u300d\u3053\u3068\u81ea\u4f53\u304c\u6cbb\u7642\u306e\u4e00\u90e8\u3068\u3044\u3046\u5074\u9762\u304c\u3042\u308a\u307e\u3059\u3002\u9023\u4f11\u306e\u8c37\u9593\u3092\u3069\u3046\u7d44\u3080\u304b\u306f\u3001\u5916\u6765\u904b\u55b6\u306e\u8155\u306e\u898b\u305b\u3069\u3053\u308d\u3067\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642 \u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\u306e\u4e0b\u8aad\u307f
\n\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u7d50\u679c\u3092\u3001\u6b63\u5f0f\u306a\u691c\u8a0e\u4f1a\uff08\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\uff09\u306b\u304b\u3051\u308b\u524d\u306b\u8aad\u307f\u8fbc\u3080\u4f1a\u3067\u3059\u3002\u4ed6\u65bd\u8a2d\u3068\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u3064\u306a\u304e\u3001\u75c5\u7406\u30fb\u30b2\u30ce\u30e0\u306e\u8aad\u307f\u65b9\u3068\u6cbb\u7642\u306e\u65b9\u91dd\u3092\u5206\u3051\u3066\u691c\u8a0e\u3057\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u691c\u67fb\u7d50\u679c\u304c\u305d\u306e\u307e\u307e\u6cbb\u7642\u306b\u3064\u306a\u304c\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u5909\u7570\u306e\u610f\u5473\u3065\u3051\u3001\u4f7f\u3048\u308b\u85ac\u306e\u6709\u7121\u3001\u81e8\u5e8a\u8a66\u9a13\u3078\u306e\u5230\u9054\u53ef\u80fd\u6027\u3092\u4e00\u3064\u305a\u3064\u78ba\u304b\u3081\u308b\u4f5c\u696d\u3092\u3001\u5b9f\u969b\u306e\u5834\u3067\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u4f5c\u6210\u306e\u305f\u3081\u306e\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u7814\u4fee\u4f1a
\n\u5b66\u4f1a\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u4f5c\u6210\u59d4\u54e1\u4f1a\u304c\u4e3b\u50ac\u3059\u308b\u30aa\u30f3\u30e9\u30a4\u30f3\u7814\u4fee\u306b\u3001\u5f53\u79d1\u304b\u3089\u3082\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u6587\u732e\u3092\u3069\u3046\u691c\u7d22\u3057\u3001\u3069\u3046\u9078\u3073\u3001\u3069\u3046\u8a55\u4fa1\u3057\u3066\u307e\u3068\u3081\u308b\u304b\u3068\u3044\u3046\u3001\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u306e\u624b\u9806\u306b\u3064\u3044\u3066\u306e\u8b1b\u7fa9\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u8ab0\u304b\u306e\u610f\u898b\u306e\u96c6\u307e\u308a\u3067\u306f\u306a\u304f\u3001\u6c7a\u307e\u3063\u305f\u624b\u9806\u3067\u4f5c\u3089\u308c\u308b\u6210\u679c\u7269\u3067\u3059\u3002\u305d\u306e\u624b\u9806\u3092\u77e5\u3063\u3066\u304a\u304f\u3068\u3001\u63a8\u5968\u306e\u5f37\u3055\u306e\u8aad\u307f\u65b9\u304c\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u533b\u5b66\u79d14\u5e74\u751f\u306e\u81e8\u5e8a\u5b9f\u7fd2\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u5e74\u6b21\u66f4\u65b0
\n\u6765\u5e74\u5ea6\u306b\u5411\u3051\u3066\u3001\u5185\u79d1\u5404\u79d1\u306e\u5b9f\u7fd2\u5185\u5bb9\u3092\u898b\u76f4\u3059\u4f5c\u696d\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002\u4f55\u3092\u898b\u3066\u3082\u3089\u3044\u3001\u4f55\u3092\u3084\u3063\u3066\u3082\u3089\u3046\u304b\u3092\u79d1\u3054\u3068\u306b\u66f8\u304d\u51fa\u3057\u3066\u3044\u304d\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u5b9f\u7fd2\u306e\u4e2d\u8eab\u306f\u6bce\u5e74\u898b\u76f4\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u300c\u3082\u3063\u3068\u3053\u3046\u3057\u3066\u307b\u3057\u3044\u300d\u3068\u3044\u3046\u58f0\u306f\u3001\u5b9f\u969b\u306b\u7fcc\u5e74\u306e\u5f62\u306b\u53cd\u6620\u3055\u308c\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u4eca\u5e74\u5ea6\u306e\u9662\u5185\u533b\u7642\u5b89\u5168\u9031\u9593\u306e\u30c6\u30fc\u30de\u306f\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5
\n\u5f53\u9662\u306e\u533b\u7642\u5b89\u5168\u9031\u9593\uff082026\u5e749\u670814\u65e5\u301c18\u65e5\uff09\u306e\u30c6\u30fc\u30de\u304c\u300c\u30c1\u30fc\u30e0\u3067\u652f\u3048\u308b\u304c\u3093\u85ac\u7269\u7642\u6cd5\u306e\u5b89\u5168\u300d\u306b\u6c7a\u307e\u308a\u3001\u9662\u5185\u3067\u30dd\u30b9\u30bf\u30fc\u30fb\u6a19\u8a9e\u306e\u52df\u96c6\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u6297\u304c\u3093\u5264\u306e\u6295\u4e0e\u306f\u3001\u533b\u5e2b\u30fb\u85ac\u5264\u5e2b\u30fb\u770b\u8b77\u5e2b\u306e\u3044\u305a\u308c\u304b\u4e00\u4eba\u3067\u3082\u78ba\u8a8d\u3092\u6b20\u304f\u3068\u4e8b\u6545\u306b\u306a\u308a\u5f97\u307e\u3059\u3002\u75c5\u9662\u5168\u4f53\u306e\u30c6\u30fc\u30de\u306b\u9078\u3070\u308c\u308b\u3053\u3068\u81ea\u4f53\u304c\u3001\u3053\u306e\u9818\u57df\u306e\u6027\u683c\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u203b \u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u30fb\u75c7\u4f8b\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u542b\u307f\u307e\u305b\u3093\u3002\u5f53\u79d1\u306e\u6d3b\u52d5\u3092\u4e00\u822c\u5316\u3057\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500
\n\u25a0 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\u30cb\u30e5\u30fc\u30b9<\/p>\n
<\/p>\n
\u30fb\u30c6\u30bb\u30f3\u30c8\u30ea\u30af\uff08\u30a2\u30c6\u30be\u30ea\u30ba\u30de\u30d6\uff09\u3001MSI-High \u306e\u7d50\u8178\u304c\u3093\u306e\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u56fd\u5185\u3067\u9069\u5fdc\u62e1\u5927\u3092\u7533\u8acb\u3014\u627f\u8a8d\u7533\u8acb\u3015<\/p>\n
2026\u5e748\u670814\u65e5\u3001\u4e2d\u5916\u88fd\u85ac\u304c\u3001\u9ad8\u983b\u5ea6\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u4e0d\u5b89\u5b9a\u6027\uff08MSI-High\uff09\u3092\u6709\u3059\u308b\u7d50\u8178\u304c\u3093\u306b\u5bfe\u3059\u308b\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u306b\u3064\u3044\u3066\u3001\u6210\u4eba\u304a\u3088\u3073\u5c0f\u5150\u3092\u5bfe\u8c61\u3068\u3059\u308b\u9069\u5fdc\u62e1\u5927\u306e\u627f\u8a8d\u7533\u8acb\u3092\u539a\u751f\u52b4\u50cd\u7701\u306b\u884c\u3063\u305f\u3068\u767a\u8868\u3057\u307e\u3057\u305f\u3002\u6839\u62e0\u3068\u306a\u3063\u305f\u306e\u306f\u3001\u6d77\u5916\u3067\u884c\u308f\u308c\u305f\u7b2c\u2162\u76f8\u533b\u5e2b\u4e3b\u5c0e\u6cbb\u9a13 ATOMIC \u8a66\u9a13\uff08Alliance A021502\uff09\u3067\u3059\u3002\u8a66\u9a13\u306e\u5185\u5bb9\u3068\u6210\u7e3e\u306f\u4e0b\u306e\u300c\u4eca\u9031\u306e\u4e00\u5831\u300d\u3067\u7d39\u4ecb\u3057\u307e\u3059\u3002
\n\u6bb5\u968e\u306b\u3054\u6ce8\u610f\u304f\u3060\u3055\u3044\u3002\u3053\u308c\u306f\u627f\u8a8d\u7533\u8acb\u3067\u3042\u3063\u3066\u3001\u627f\u8a8d\u3067\u3082\u4fdd\u967a\u9069\u7528\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u65e5\u672c\u3067\u306f\u3001\u4f01\u696d\u304c\u7533\u8acb\u3057\u3001\u5be9\u67fb\u3092\u7d4c\u3066\u627f\u8a8d\u3055\u308c\u3001\u305d\u306e\u5f8c\u306b\u85ac\u4fa1\u57fa\u6e96\u3078\u53ce\u8f09\u3055\u308c\u3066\u3001\u306f\u3058\u3081\u3066\u4fdd\u967a\u8a3a\u7642\u3067\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u73fe\u6642\u70b9\u3067\u3053\u306e\u4f7f\u3044\u65b9\u306f\u3067\u304d\u307e\u305b\u3093\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u5927\u8178\u304c\u3093\u306e\u8853\u5f8c\u88dc\u52a9\u5316\u5b66\u7642\u6cd5\u306f\u3001\u9577\u304f mFOLFOX6 \u306a\u3069\u306e\u5316\u5b66\u7642\u6cd5\u304c\u4e2d\u5fc3\u3067\u3057\u305f\u3002\u305d\u3053\u306b\u3001\u907a\u4f1d\u5b50\u306e\u72b6\u614b\uff08dMMR\uff0fMSI-High\uff09\u3067\u9078\u3093\u3060\u60a3\u8005\u3055\u3093\u306b\u9650\u3063\u3066\u514d\u75ab\u7642\u6cd5\u3092\u8db3\u3059\u3068\u3044\u3046\u8a2d\u8a08\u304c\u5165\u3063\u3066\u304d\u307e\u3059\u3002\u6d88\u5316\u5668\u304c\u3093\u30fb\u514d\u75ab\u7642\u6cd5\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u304c\u4e00\u3064\u306b\u3064\u306a\u304c\u308b\u8a71\u984c\u3067\u3059\u3002<\/p>\n
\u51fa\u5178\uff1a\u4e2d\u5916\u88fd\u85ac \u30cb\u30e5\u30fc\u30b9\u30ea\u30ea\u30fc\u30b9\uff082026\u5e748\u670814\u65e5\uff09\u300c\u30c6\u30bb\u30f3\u30c8\u30ea\u30af\u3001\u9ad8\u983b\u5ea6\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u4e0d\u5b89\u5b9a\u6027\uff08MSI-High\uff09\u3092\u6709\u3059\u308b\u7d50\u8178\u304c\u3093\u306b\u5bfe\u3059\u308b\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u3068\u3057\u3066\u9069\u5fdc\u62e1\u5927\u7533\u8acb\u300d<\/a><\/p>\n <\/p>\n \u30fb\u30b8\u30d1\u30ec\u30eb\u30c1\u30cb\u30d6\u3001EGFR \u30a8\u30af\u30bd\u30f320\u633f\u5165\u5909\u7570\u306e\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u4e00\u6b21\u6cbb\u7642\u3067\u7b2c\u2162\u76f8\u8a66\u9a13\u306e\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3092\u9054\u6210\u3014\u8a66\u9a13\u7d50\u679c\uff08\u56fd\u5185\u672a\u627f\u8a8d\uff09\u3015 <\/p>\n \u203b\u4eca\u9031\u306f\u3001\u816b\u760d\u9818\u57df\u3067\u65b0\u305f\u306b\u627f\u8a8d\u3055\u308c\u305f\u85ac\u30fb\u85ac\u4fa1\u57fa\u6e96\u306b\u53ce\u8f09\u3055\u308c\u305f\u85ac\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n \u25a0 \u4eca\u9031\u306e\u4e00\u5831\uff08\u6ce8\u76ee\u8ad6\u6587\uff09\u3014\u5927\u8178\u304c\u3093\uff0f\u514d\u75ab\u7642\u6cd5\u3015<\/p>\n <\/p>\n \u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\u6a5f\u80fd\u304c\u6b20\u3051\u305f Stage\u2162 \u7d50\u8178\u304c\u3093\u306b\u3001\u8853\u5f8c\u306e\u5316\u5b66\u7642\u6cd5\u3078\u514d\u75ab\u7642\u6cd5\u3092\u8db3\u3059 \u2015 ATOMIC \u8a66\u9a13 <\/p>\n \u30fbStage\u2162 \u7d50\u8178\u304c\u3093\u306e\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u306f\u3001\u30d5\u30eb\u30aa\u30ed\u30d4\u30ea\u30df\u30b8\u30f3\u3068\u30aa\u30ad\u30b5\u30ea\u30d7\u30e9\u30c1\u30f3\u306e\u4f75\u7528\uff08mFOLFOX6 \u306a\u3069\uff09\u304c\u6a19\u6e96\u3067\u3059\u3002\u3053\u3053\u306b\u6297 PD-L1 \u6297\u4f53\u30a2\u30c6\u30be\u30ea\u30ba\u30de\u30d6\u3092\u52a0\u3048\u308b\u3053\u3068\u3067\u3001\u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\u6a5f\u80fd\u6b20\u640d\uff08dMMR\uff09\u306e\u60a3\u8005\u3055\u3093\u306e\u6210\u7e3e\u304c\u826f\u304f\u306a\u308b\u304b\u306f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002 <\/p>\n \u81e8\u5e8a\u7684\u610f\u7fa9\uff1a\u8853\u5f8c\u88dc\u52a9\u7642\u6cd5\u306f\u300c\u518d\u767a\u3059\u308b\u304b\u3069\u3046\u304b\u5206\u304b\u3089\u306a\u3044\u4eba\u306b\u3082\u3001\u518d\u767a\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u6cbb\u7642\u3092\u884c\u3046\u300d\u3068\u3044\u3046\u96e3\u3057\u3055\u3092\u3082\u3064\u9818\u57df\u3067\u3059\u3002\u6709\u52b9\u6027\u304c\u793a\u3055\u308c\u305f\u4e00\u65b9\u3067 Grade 3\u20134 \u306e\u6709\u5bb3\u4e8b\u8c61\u306f\u5897\u3048\u3066\u304a\u308a\u3001\u8ab0\u306b\u52e7\u3081\u308b\u304b\u3068\u3044\u3046\u8b70\u8ad6\u306f\u3053\u3053\u304b\u3089\u59cb\u307e\u308a\u307e\u3059\u3002\u4e0a\u306e\u30cb\u30e5\u30fc\u30b9\u3067\u7d39\u4ecb\u3057\u305f\u56fd\u5185\u306e\u9069\u5fdc\u62e1\u5927\u7533\u8acb\u306f\u3001\u3053\u306e\u8a66\u9a13\u306e\u7d50\u679c\u306b\u57fa\u3065\u304f\u3082\u306e\u3067\u3059\u3002<\/p>\n <\/p>\n \u51fa\u5178\uff08PubMed \u53ce\u8f09\uff0fPMID: 41880612\uff09\uff1aDOI: 10.1056\/NEJMoa2507874<\/a>\uff08Sinicrope FA, et al. N Engl J Med 2026\uff09 <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n 9\/9\uff08\u6c34\uff09\u4ee4\u548c8\u5e74\u5ea6\u300c\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u7b49\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306e\u4f1a\u300d <\/p>\n \u5f53\u79d1\u306e\u898b\u5b66\u30fb\u5b9f\u7fd2\u30fb\u9032\u8def\u76f8\u8ac7\u306f\u968f\u6642\u53d7\u3051\u4ed8\u3051\u3066\u3044\u307e\u3059 <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 <\/p>\n \u4eca\u9031\u306e\u30cb\u30e5\u30fc\u30b9\u3068\u8ad6\u6587\u306b\u4f55\u5ea6\u3082\u51fa\u3066\u304d\u305f dMMR \u3068 MSI-High \u306f\u3001\u540c\u3058\u73fe\u8c61\u3092\u5225\u306e\u89d2\u5ea6\u304b\u3089\u898b\u305f\u8a00\u8449\u3067\u3059\u3002\u9806\u3092\u8ffd\u3063\u3066\u307f\u307e\u3059\u3002<\/p>\n \u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u3068\u304d\u3001DNA \u306e\u8907\u88fd\u306b\u306f\u3069\u3046\u3057\u3066\u3082\u5199\u3057\u9593\u9055\u3044\u304c\u8d77\u3053\u308a\u307e\u3059\u3002\u3053\u308c\u3092\u898b\u3064\u3051\u3066\u76f4\u3059\u4ed5\u7d44\u307f\u304c\u30df\u30b9\u30de\u30c3\u30c1\u4fee\u5fa9\uff08mismatch repair, MMR\uff09\u3067\u3001MLH1\u30fbMSH2\u30fbMSH6\u30fbPMS2 \u3068\u3044\u3063\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u62c5\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u4ed5\u7d44\u307f\u304c\u50cd\u304b\u306a\u304f\u306a\u3063\u305f\u72b6\u614b\u3092\u3001\u6a5f\u80fd\u6b20\u640d\uff08deficient\uff09\u306e d \u3092\u3064\u3051\u3066 dMMR \u3068\u547c\u3073\u307e\u3059\u3002\u514d\u75ab\u67d3\u8272\u3067\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u67d3\u307e\u3089\u306a\u3044\u3053\u3068\u3067\u5224\u5b9a\u3055\u308c\u307e\u3059\u3002<\/p>\n \u4fee\u5fa9\u304c\u52b9\u304b\u306a\u3044\u3068\u3001\u540c\u3058\u77ed\u3044\u914d\u5217\u304c\u7e70\u308a\u8fd4\u3057\u3066\u3044\u308b\u9818\u57df\uff08\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\uff09\u3067\u3001\u7e70\u308a\u8fd4\u3057\u306e\u56de\u6570\u304c\u305a\u308c\u305f\u5909\u7570\u304c\u6e9c\u307e\u3063\u3066\u3044\u304d\u307e\u3059\u3002\u3053\u306e\u300c\u305a\u308c\u300d\u304c\u9ad8\u3044\u983b\u5ea6\u3067\u898b\u3089\u308c\u308b\u72b6\u614b\u304c\u3001\u9ad8\u983b\u5ea6\u30de\u30a4\u30af\u30ed\u30b5\u30c6\u30e9\u30a4\u30c8\u4e0d\u5b89\u5b9a\u6027\uff08MSI-High\uff09\u3067\u3059\u3002\u3064\u307e\u308a dMMR \u306f\u539f\u56e0\u5074\u306e\u547c\u3073\u540d\u3001MSI-High \u306f\u7d50\u679c\u5074\u306e\u547c\u3073\u540d\u3067\u3001\u5b9f\u52d9\u4e0a\u306f\u307b\u307c\u540c\u3058\u96c6\u56e3\u3092\u6307\u3057\u307e\u3059\u3002<\/p>\n \u3053\u3053\u304b\u3089\u304c\u9762\u767d\u3044\u3068\u3053\u308d\u3067\u3059\u3002\u5909\u7570\u304c\u6e9c\u307e\u308b\u3068\u3001\u304c\u3093\u7d30\u80de\u306f\u672c\u6765\u306e\u4f53\u306b\u306f\u306a\u3044\u30a2\u30df\u30ce\u9178\u914d\u5217\uff08\u30cd\u30aa\u30a2\u30f3\u30c1\u30b2\u30f3\uff09\u3092\u591a\u304f\u4f5c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002\u514d\u75ab\u306e\u5074\u304b\u3089\u898b\u308c\u3070\u300c\u898b\u6163\u308c\u306a\u3044\u76ee\u5370\u300d\u304c\u5897\u3048\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u305d\u306e\u3076\u3093\u7570\u7269\u3068\u3057\u3066\u8a8d\u8b58\u3055\u308c\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u85ac\u306f\u3001\u3053\u306e\u8a8d\u8b58\u306b\u30d6\u30ec\u30fc\u30ad\u304c\u304b\u304b\u3063\u3066\u3044\u308b\u72b6\u614b\u3092\u5916\u3059\u85ac\u3067\u3059\u304b\u3089\u3001\u76ee\u5370\u304c\u591a\u3044 dMMR\uff0fMSI-High \u306e\u304c\u3093\u3067\u306f\u52b9\u679c\u304c\u671f\u5f85\u3057\u3084\u3059\u3044\u3002\u3053\u308c\u304c\u3001\u4eca\u9031\u7d39\u4ecb\u3057\u305f ATOMIC \u8a66\u9a13\u304c dMMR \u306e\u60a3\u8005\u3055\u3093\u306b\u7d5e\u3063\u3066\u884c\u308f\u308c\u305f\u7406\u7531\u3067\u3059\u3002<\/p>\n dMMR\uff0fMSI-High \u306f\u5927\u8178\u304c\u3093\u306e\u4e00\u90e8\u306b\u307f\u3089\u308c\u3001\u907a\u4f1d\u6027\u306e\u30ea\u30f3\u30c1\u75c7\u5019\u7fa4\u3068\u95a2\u4fc2\u3059\u308b\u3053\u3068\u3082\u3042\u308b\u305f\u3081\u3001\u5224\u660e\u3057\u305f\u5834\u5408\u306b\u306f\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u3064\u306a\u3050\u6d41\u308c\u3082\u7528\u610f\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u691c\u67fb\u305d\u306e\u3082\u306e\u306f\u3001\u514d\u75ab\u67d3\u8272\u3084 MSI \u691c\u67fb\u3001\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u4e00\u90e8\u3068\u3057\u3066\u3001\u3059\u3067\u306b\u65e5\u5e38\u8a3a\u7642\u306e\u306a\u304b\u3067\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u4e00\u3064\u306e\u691c\u67fb\u7d50\u679c\u304c\u3001\u85ac\u306e\u9078\u629e\u306b\u3082\u3001\u3054\u5bb6\u65cf\u306e\u5065\u5eb7\u306b\u3082\u3064\u306a\u304c\u3063\u3066\u3044\u304f\u3002\u816b\u760d\u5185\u79d1\u306e\u4ed5\u4e8b\u306e\u5e83\u304c\u308a\u304c\u898b\u3048\u308b\u3068\u3053\u308d\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e748\u6708\u7b2c2\u9031\uff0f8\u670810\u65e5\u301c8\u670816\u65e5\uff09 \u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1 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