\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff082026\u5e747\u6708\u7b2c5\u9031\uff0f7\u670827\u65e5\u301c8\u67082\u65e5\uff09
\n\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1<\/p>\n
<\/p>\n
\u816b\u760d\u5185\u79d1\u306b\u95a2\u5fc3\u306e\u3042\u308b\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u65b9\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u306e\u6d3b\u52d5\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u4e16\u306e\u4e2d\u306e\u52d5\u304d\uff08\u8ad6\u6587\u30fb\u5b66\u4f1a\u30fb\u5236\u5ea6\uff09\u3092\u3001\u6bce\u9031\u307e\u3068\u3081\u3066\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002\u4eca\u9031\u306f\u3001\u907a\u4f1d\u5b50\u5909\u7570\u3092\u76ee\u5370\u306b\u85ac\u3092\u9078\u3076\u8a71\u3068\u3001\u65b0\u3057\u3044\u85ac\u304c\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u307e\u3067\u306e\u624b\u7d9a\u304d\u3092\u4e00\u7dd2\u306b\u898b\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n
\u25a0 \u4eca\u9031\u306e\u5f53\u79d1\u304b\u3089<\/p>\n
<\/p>\n
\u30fb\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u305f\u3081\u306e\u816b\u760d\u5185\u79d1\u8aac\u660e\u4f1a\u3092\u958b\u50ac\u3057\u307e\u3057\u305f
\n\u816b\u760d\u5185\u79d1\u306e\u4ed5\u4e8b\u3084\u9032\u8def\u306b\u3064\u3044\u3066\u3001\u5f53\u79d1\u306e\u30b9\u30bf\u30c3\u30d5\u3068\u5c11\u4eba\u6570\u3067\u8a71\u305b\u308b\u4f1a\u3092\u958b\u304d\u307e\u3057\u305f\u3002\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u53c2\u52a0\u306f30\u540d\u3014\u5b9f\u30c7\u30fc\u30bf\u3015\u3002\u5f53\u79d1\u3067\u7814\u4fee\u3057\u305f\u5148\u8f29\u533b\u5e2b\u306b\u3082\u52a0\u308f\u3063\u3066\u3044\u305f\u3060\u304d\u3001\u6559\u54e1\u304b\u3089\u805e\u304f\u306e\u3068\u306f\u9055\u3046\u5b9f\u611f\u306e\u3042\u308b\u8a71\u304c\u4ea4\u308f\u3055\u308c\u307e\u3057\u305f\u3002\u4f1a\u306e\u4e2d\u3067\u306f\u3001\u5168\u56fd\u304b\u3089\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u304c\u96c6\u307e\u308b\u816b\u760d\u5185\u79d1\u30bb\u30df\u30ca\u30fc\u3078\u306e\u53c2\u52a0\u5831\u544a\u3082\u3042\u308a\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u540c\u3058\u95a2\u5fc3\u3092\u3082\u3064\u4eba\u3068\u51fa\u4f1a\u3048\u308b\u5834\u3067\u3059\u3002\u5b66\u5e74\u3084\u6240\u5c5e\u3092\u554f\u308f\u305a\u3001\u307e\u305a\u8a71\u3092\u805e\u3044\u3066\u307f\u308b\u3068\u3053\u308d\u304b\u3089\u59cb\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u539f\u767a\u4e0d\u660e\u304c\u3093\u30fb\u5e0c\u5c11\u304c\u3093\u306e\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\uff08\u30ad\u30e3\u30f3\u30b5\u30fc\u30dc\u30fc\u30c9\uff09
\n\u8a3a\u65ad\u3084\u6cbb\u7642\u65b9\u91dd\u306e\u6c7a\u3081\u306b\u304f\u3044\u304c\u3093\u306b\u3064\u3044\u3066\u3001\u591a\u304f\u306e\u8a3a\u7642\u79d1\u30fb\u591a\u8077\u7a2e\u304c\u96c6\u307e\u3063\u3066\u65b9\u91dd\u3092\u691c\u8a0e\u3059\u308b\u5b9a\u4f8b\u306e\u4f1a\u8b70\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u300c\u3069\u306e\u81d3\u5668\u306e\u304c\u3093\u304b\u7279\u5b9a\u3057\u306b\u304f\u3044\u300d\u30b1\u30fc\u30b9\u306b\u30c1\u30fc\u30e0\u3067\u5411\u304d\u5408\u3046\u3001\u816b\u760d\u5185\u79d1\u306a\u3089\u3067\u306f\u306e\u6a2a\u65ad\u7684\u306a\u8a3a\u7642\u306b\u89e6\u308c\u3089\u308c\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\uff0f\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb\u306e\u4e0b\u8aad\u307f\uff08\u30d7\u30ecEP\uff09
\n\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u7d50\u679c\u3092\u672c\u756a\u306e\u4f1a\u8b70\u3067\u8b70\u8ad6\u3059\u308b\u524d\u306b\u3001\u4ed6\u65bd\u8a2d\u3068\u5408\u540c\u3067\u30aa\u30f3\u30e9\u30a4\u30f3\u306e\u4e0b\u8aad\u307f\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u691c\u67fb\u7d50\u679c\u3092\u6cbb\u7642\u63a8\u5968\u3078\u7ffb\u8a33\u3059\u308b\u8b70\u8ad6\u3092\u3001\u6e96\u5099\u6bb5\u968e\u304b\u3089\u9593\u8fd1\u3067\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u304c\u3093\u30b2\u30ce\u30e0\u691c\u67fb\u306e\u8a18\u9332\u904b\u7528\u306e\u6574\u5099
\n\u691c\u67fb\u306e\u8aac\u660e\u3084\u7d50\u679c\u306e\u8fd4\u5374\u3092\u3001\u4fdd\u967a\u8a3a\u7642\u306e\u8981\u4ef6\u306b\u6cbf\u3063\u3066\u78ba\u5b9f\u306b\u8a18\u9332\u3067\u304d\u308b\u3088\u3046\u3001\u30ab\u30eb\u30c6\u8a18\u8f09\u306e\u30c6\u30f3\u30d7\u30ec\u30fc\u30c8\u3092\u4e8b\u52d9\u90e8\u9580\u30fb\u95a2\u4fc2\u8a3a\u7642\u79d1\u3068\u4e00\u7dd2\u306b\u6574\u3048\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u65b0\u3057\u3044\u533b\u7642\u3092\u9662\u5185\u306b\u6839\u3065\u304b\u305b\u308b\u4ed5\u7d44\u307f\u3065\u304f\u308a\u3082\u3001\u816b\u760d\u5185\u79d1\u533b\u306e\u4ed5\u4e8b\u306e\u3072\u3068\u3064\u3067\u3059\u3002<\/p>\n
<\/p>\n
\u30fb\u9662\u5185\u306e\u533b\u7642\u5b89\u5168\u306b\u95a2\u3059\u308b\u4f1a\u8b70
\n\u5404\u90e8\u7f72\u306e\u62c5\u5f53\u8005\u304c\u96c6\u307e\u308a\u3001\u5b89\u5168\u306a\u533b\u7642\u3092\u63d0\u4f9b\u3059\u308b\u305f\u3081\u306e\u53d6\u308a\u7d44\u307f\u3092\u5171\u6709\u30fb\u78ba\u8a8d\u3059\u308b\u5b9a\u4f8b\u306e\u4f1a\u8b70\u306b\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u6297\u304c\u3093\u5264\u306f\u52b9\u679c\u3068\u526f\u4f5c\u7528\u304c\u80cc\u4e2d\u5408\u308f\u305b\u3067\u3059\u3002\u5b89\u5168\u7ba1\u7406\u306e\u8996\u70b9\u306f\u3001\u3053\u306e\u9818\u57df\u3067\u306f\u7279\u306b\u91cd\u307f\u3092\u3082\u3061\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u203b \u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u30fb\u75c7\u4f8b\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u542b\u307f\u307e\u305b\u3093\u3002\u5f53\u79d1\u306e\u6d3b\u52d5\u3092\u4e00\u822c\u5316\u3057\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
<\/p>\n
\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n
\u25a0 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\u30cb\u30e5\u30fc\u30b9<\/p>\n
<\/p>\n
\u30fb\u30d2\u30a2\u30cb\u30e5\u30aa\u932010 mg\uff08\u30bb\u30d0\u30d9\u30eb\u30c1\u30cb\u30d6\uff09\u3001HER2\u907a\u4f1d\u5b50\u5909\u7570\u967d\u6027\u306e\u80ba\u304c\u3093\u3092\u5bfe\u8c61\u306b\u90e8\u4f1a\u3067\u5be9\u8b70\u3014\u90e8\u4f1a\u5be9\u8b70\uff08\u627f\u8a8d\u524d\uff09\u3015
\n2026\u5e747\u670827\u65e5\uff08\u6708\uff09\u306b\u958b\u304b\u308c\u305f\u539a\u751f\u52b4\u50cd\u7701\u306e\u85ac\u4e8b\u5be9\u8b70\u4f1a \u533b\u85ac\u54c1\u7b2c\u4e8c\u90e8\u4f1a\u3067\u3001\u30d2\u30a2\u30cb\u30e5\u30aa\u932010 mg \u306e\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u306e\u53ef\u5426\u304c\u5be9\u8b70\u3055\u308c\u307e\u3057\u305f\uff08\u8b70\u984c12\uff09\u3002\u5bfe\u8c61\u3068\u3057\u3066\u60f3\u5b9a\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001HER2\uff08ERBB2\uff09\u907a\u4f1d\u5b50\u5909\u7570\u306e\u3042\u308b\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u3067\u3059\u3002\u90e8\u4f1a\u306f\u975e\u516c\u958b\u3067\u3001\u8b70\u4e8b\u8981\u65e8\u306f\u4f5c\u6210\u6642\u70b9\u3067\u306f\u516c\u8868\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u6b63\u5f0f\u306a\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u3001\u305d\u306e\u3042\u3068\u306e\u4fdd\u967a\u9069\u7528\uff08\u85ac\u4fa1\u53ce\u8f09\uff09\u306f\u3053\u308c\u304b\u3089\u306e\u624b\u7d9a\u304d\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n
\u5b66\u3073\u3069\u3053\u308d\uff1a\u80ba\u304c\u3093\u3067\u306f EGFR \u3084 ALK \u306e\u5909\u7570\u30fb\u878d\u5408\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u3066\u85ac\u3092\u9078\u3076\u6d41\u308c\u304c\u5b9a\u7740\u3057\u3066\u3044\u307e\u3059\u304c\u3001HER2 \u5909\u7570\u3082\u305d\u306e\u4e00\u3064\u306b\u52a0\u308f\u308d\u3046\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u88cf\u4ed8\u3051\u3068\u306a\u3063\u305f\u8a66\u9a13\u306f\u4e0b\u306e\u300c\u4eca\u9031\u306e\u4e00\u5831\u300d\u3067\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n
\u51fa\u5178\uff1a\u539a\u751f\u52b4\u50cd\u7701\u300c\u85ac\u4e8b\u5be9\u8b70\u4f1a \u533b\u85ac\u54c1\u7b2c\u4e8c\u90e8\u4f1a\uff08\u4ee4\u548c8\u5e747\u670827\u65e5\u958b\u50ac\uff09\u300d\u958b\u50ac\u6848\u5185<\/a> \uff0f\u540c \u8b70\u984c\uff08\u5225\u7d19\u30fbPDF\uff09\u00a0<\/a><\/p>\n <\/p>\n \u30fbPIK3CA\u907a\u4f1d\u5b50\u5909\u7570\u306e\u3042\u308b\u5375\u5de3\u660e\u7d30\u80de\u304c\u3093\u6cbb\u7642\u85ac\u306b\u3064\u3044\u3066\u3001\u9069\u6b63\u4f7f\u7528\u306e\u304a\u9858\u3044\u304c\u51fa\u3055\u308c\u307e\u3057\u305f <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n \u25a0 \u4eca\u9031\u306e\u4e00\u5831\uff08\u6ce8\u76ee\u8ad6\u6587\uff09\u3014\u80ba\u304c\u3093\uff0f\u7cbe\u5bc6\u533b\u7642\u3015<\/p>\n <\/p>\n HER2\u907a\u4f1d\u5b50\u5909\u7570\u306e\u3042\u308b\u9032\u884c\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306b\u5bfe\u3059\u308b\u30bb\u30d0\u30d9\u30eb\u30c1\u30cb\u30d6 \u2015 SOHO-01\u8a66\u9a13 <\/p>\n \u30fb\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306e\u3046\u3061 HER2 \u907a\u4f1d\u5b50\u5909\u7570\u3092\u3082\u3064\u306e\u306f 2\u301c4% \u3068\u3055\u308c\u307e\u3059\u3002\u3053\u306e\u8a66\u9a13\u3067\u306f\u3001\u5c40\u6240\u9032\u884c\u307e\u305f\u306f\u8ee2\u79fb\u306e\u3042\u308b HER2 \u5909\u7570\u967d\u6027\u306e\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093 209\u4f8b\u306b\u3001\u7d4c\u53e3\u306eHER2\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u963b\u5bb3\u85ac\u30bb\u30d0\u30d9\u30eb\u30c1\u30cb\u30d6\u3092\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002 <\/p>\n \u81e8\u5e8a\u7684\u610f\u7fa9\uff1a\u98f2\u307f\u85ac\u3067\u3001\u3057\u304b\u3082\u907a\u4f1d\u5b50\u5909\u7570\u3092\u76ee\u5370\u306b\u52b9\u679c\u3092\u72d9\u3048\u308b\u2015\u3068\u3044\u3046\u9078\u629e\u80a2\u304c\u80ba\u304c\u3093\u3067\u307e\u305f\u4e00\u3064\u5897\u3048\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u4e0a\u306e\u30cb\u30e5\u30fc\u30b9\u3067\u53d6\u308a\u4e0a\u3052\u305f\u90e8\u4f1a\u5be9\u8b70\u306f\u3001\u3053\u306e\u8a66\u9a13\u304c\u571f\u53f0\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5236\u5ea6\uff08\u627f\u8a8d\u306e\u624b\u7d9a\u304d\uff09\u3068\u6839\u62e0\uff08\u8a66\u9a13\u306e\u6570\u5b57\uff09\u3092\u4e26\u3079\u3066\u898b\u308b\u3068\u3001\u65b0\u3057\u3044\u6cbb\u7642\u304c\u3069\u3046\u5b9f\u88c5\u3055\u308c\u3066\u3044\u304f\u306e\u304b\u304c\u3064\u304b\u3081\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n \u51fa\u5178\uff08PubMed \u53ce\u8f09\uff0fPMID: 41104928\uff09\uff1aDOI: 10.1056\/NEJMoa2511065<\/a> \uff08Le X, et al. N Engl J Med 2025\uff09<\/p>\n <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n \u25a0 \u5b66\u4f1a\u30fb\u30bb\u30df\u30ca\u30fc\uff0f\u884c\u4e8b<\/p>\n <\/p>\n 8\/21\uff08\u91d1\uff09\u3064\u304f\u3070AI\u30d6\u30fc\u30b9\u30c8\u56fd\u969b\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 \u2015 \u75c5\u7406\u753b\u50cf\u8a3a\u65ad\u3068\u304c\u3093\u7814\u7a76\u306b\u304a\u3051\u308bAI <\/p>\n 9\/9\uff08\u6c34\uff09\u4ee4\u548c8\u5e74\u5ea6\u300c\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u7b49\u3092\u30b5\u30dd\u30fc\u30c8\u3059\u308b\u305f\u3081\u306e\u4f1a\u300d <\/p>\n \u5f53\u79d1\u306e\u898b\u5b66\u30fb\u5b9f\u7fd2\u30fb\u9032\u8def\u76f8\u8ac7\u306f\u968f\u6642\u53d7\u3051\u4ed8\u3051\u3066\u3044\u307e\u3059 <\/p>\n \u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n \u25a0 \u3072\u3068\u3053\u3068\u30b3\u30e9\u30e0 \u2015 \u65b0\u3057\u3044\u85ac\u304c\u4f7f\u3048\u308b\u3088\u3046\u306b\u306a\u308b\u307e\u3067<\/p>\n <\/p>\n \u4eca\u9031\u306e\u30cb\u30e5\u30fc\u30b9\u3067\u300c\u90e8\u4f1a\u3067\u5be9\u8b70\u300d\u300c\u627f\u8a8d\u300d\u300c\u85ac\u4fa1\u53ce\u8f09\u300d\u3068\u3044\u3046\u8a00\u8449\u304c\u4e26\u3073\u307e\u3057\u305f\u3002\u65e5\u672c\u3067\u306f\u3001\u65b0\u3057\u3044\u85ac\u304c\u60a3\u8005\u3055\u3093\u306b\u5c4a\u304f\u307e\u3067\u306b\u3044\u304f\u3064\u304b\u306e\u6bb5\u968e\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305a\u88fd\u85ac\u4f01\u696d\u304c\u81e8\u5e8a\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u3092\u305d\u308d\u3048\u3066\u7533\u8acb\u3057\u3001\u72ec\u7acb\u884c\u653f\u6cd5\u4eba \u533b\u85ac\u54c1\u533b\u7642\u6a5f\u5668\u7dcf\u5408\u6a5f\u69cb\uff08PMDA\uff09\u304c\u5be9\u67fb\u3057\u307e\u3059\u3002\u305d\u306e\u7d50\u679c\u3092\u8e0f\u307e\u3048\u3066\u539a\u751f\u52b4\u50cd\u7701\u306e\u5be9\u8b70\u4f1a\uff08\u90e8\u4f1a\uff09\u3067\u5be9\u8b70\u3055\u308c\u3001\u4e86\u627f\u3055\u308c\u308b\u3068\u539a\u751f\u52b4\u50cd\u5927\u81e3\u304c\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u3092\u51fa\u3057\u307e\u3059\u3002\u305f\u3060\u3057\u3001\u627f\u8a8d\u3055\u308c\u305f\u6642\u70b9\u3067\u306f\u307e\u3060\u4fdd\u967a\u3067\u306f\u4f7f\u3048\u307e\u305b\u3093\u3002\u305d\u306e\u3042\u3068\u4e2d\u592e\u793e\u4f1a\u4fdd\u967a\u533b\u7642\u5354\u8b70\u4f1a\uff08\u4e2d\u533b\u5354\uff09\u3067\u306e\u8b70\u8ad6\u3092\u7d4c\u3066\u85ac\u4fa1\u304c\u6c7a\u307e\u308a\u3001\u85ac\u4fa1\u57fa\u6e96\u306b\u53ce\u8f09\u3055\u308c\u3066\u3001\u306f\u3058\u3081\u3066\u4fdd\u967a\u8a3a\u7642\u306e\u306a\u304b\u3067\u51e6\u65b9\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002 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\n\u51fa\u5178\uff1a\u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\u300c\u304c\u3093\u85ac\u7269\u7642\u6cd5\u30cb\u30e5\u30fc\u30b9\u300d\uff082026\u5e747\u670828\u65e5\u63b2\u8f09\uff09<\/a>\uff0f\u5927\u9d6c\u85ac\u54c1\u5de5\u696d\u300c\u30cf\u30a4\u30c4\u30a8\u30ad\u30b7\u30f3\u932010mg \u9069\u6b63\u4f7f\u7528\u306e\u304a\u9858\u3044\u300d\uff08PDF\uff09<\/a><\/p>\n
\nN Engl J Med. 2025;393(18):1819\u20131832.\uff0f\u56fd\u969b\u5171\u540c\u7b2cI\/II\u76f8\u30fb\u975e\u76f2\u691c\u591a\u65bd\u8a2d\u8a66\u9a13\uff08SOHO-01 Investigators\uff09<\/p>\n
\n\u30fb\u594f\u52b9\u7387\uff08\u816b\u760d\u304c\u4e00\u5b9a\u4ee5\u4e0a\u7e2e\u5c0f\u3057\u305f\u5272\u5408\uff09\u306f\u3001\u524d\u6cbb\u7642\u306e\u306a\u3044\u96c6\u56e3\uff0873\u4f8b\uff09\u3067 71%\uff0895%\u4fe1\u983c\u533a\u9593 59\u201381\uff09\u3001\u5316\u5b66\u7642\u6cd5\u306a\u3069\u306e\u524d\u6cbb\u7642\u304c\u3042\u308a HER2 \u6a19\u7684\u85ac\u306f\u672a\u4f7f\u7528\u306e\u96c6\u56e3\uff0881\u4f8b\uff09\u3067 64%\uff08\u540c 53\u201375\uff09\u3001HER2 \u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\u306b\u3088\u308b\u524d\u6cbb\u7642\u304c\u3042\u308b\u96c6\u56e3\uff0855\u4f8b\uff09\u3067 38%\uff08\u540c 25\u201352\uff09\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002
\n\u30fb\u594f\u52b9\u304c\u7d9a\u3044\u305f\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u524d\u6cbb\u7642\u306e\u306a\u3044\u96c6\u56e3\u3067 11.0\u304b\u6708\u3001\u524d\u6cbb\u7642\u306e\u3042\u308b\u96c6\u56e3\u3067 9.2\u304b\u6708\u3002\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f\u3001\u524d\u6cbb\u7642\u304c\u3042\u308a HER2 \u6a19\u7684\u85ac\u672a\u4f7f\u7528\u306e\u96c6\u56e3\u3067 8.3\u304b\u6708\uff08\u540c 6.9\u201312.3\uff09\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002\u4e3b\u306a\u6709\u5bb3\u4e8b\u8c61\u306f\u4e0b\u75e2\u3067\u3001\u767a\u73fe\u983b\u5ea6\u306f\u96c6\u56e3\u306b\u3088\u308a 84\u301c91%\u3001Grade 3 \u4ee5\u4e0a\u306f 5\u301c23% \u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n
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