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\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u816b\u760d\u5185\u79d1\u533b\u304c\u3069\u306e\u3088\u3046\u306b\u5c02\u9580\u6027\u3092\u8eab\u306b\u3064\u3051\u3001\u8a8d\u5b9a\u3055\u308c\u3066\u3044\u304f\u306e\u304b\u2015\u30ad\u30e3\u30ea\u30a2\u306e\u9053\u7b4b\u306b\u89e6\u308c\u3089\u308c\u307e\u3059\uff08\u4e0b\u306e\u30cb\u30e5\u30fc\u30b9\u3067\u3082\u53d6\u308a\u4e0a\u3052\u307e\u3059\uff09\u3002<\/span><\/p>\n
\n\u25a0 \u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\u30cb\u30e5\u30fc\u30b9<\/h2>\n
\n\u5bfe\u8c61\uff1aESR1\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u3001\u30db\u30eb\u30e2\u30f3\u53d7\u5bb9\u4f53\uff08ER\uff09\u967d\u6027\u30fbHER2\u9670\u6027\u306e\u4e73\u304c\u3093\u3002\u6b21\u4e16\u4ee3\u306e\u7d4c\u53e3SERD\uff08\u9078\u629e\u7684\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u53d7\u5bb9\u4f53\u5206\u89e3\u85ac\uff09\u3067\u30012026\u5e746\u670819\u65e5\u306b\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u203b\u73fe\u6642\u70b9\u3067\u306f\u85ac\u4e8b\u627f\u8a8d\u306e\u6bb5\u968e\u3067\u3001\u4fdd\u967a\u9069\u7528\uff08\u85ac\u4fa1\u53ce\u8f09\uff09\u306f\u3053\u306e\u5f8c\u306e\u624b\u7d9a\u304d\u306b\u306a\u308a\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u30db\u30eb\u30e2\u30f3\u7642\u6cd5\u304c\u52b9\u304d\u306b\u304f\u304f\u306a\u308b\u539f\u56e0\u306e\u3072\u3068\u3064ESR1\u5909\u7570\u3092\u3001\u8840\u6db2\uff08ctDNA\uff09\u3067\u6349\u3048\u3066\u85ac\u3092\u5207\u308a\u66ff\u3048\u308b\u2015\u7cbe\u5bc6\u533b\u7642\u304c\u4e73\u304c\u3093\u306e\u30db\u30eb\u30e2\u30f3\u6cbb\u7642\u306b\u3082\u5165\u3063\u3066\u304d\u305f\u4e00\u5831\u3067\u3059\u3002\u88cf\u4ed8\u3051\u3068\u306a\u3063\u305fSERENA-6\u8a66\u9a13\u306f\u3001\u4e0b\u306e\u300c\u4eca\u9031\u306e\u4e00\u5831\u300d\u3067\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/span><\/p>\n
\n\u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\u304c\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u5c02\u9580\u533b\u5236\u5ea6\u306e\u6539\u8a02\u306b\u95a2\u3059\u308b\u8aac\u660e\u4f1a\u3092\u958b\u50ac\u3057\u307e\u3057\u305f\uff082026\u5e747\u670816\u65e5\uff09\u3002\u5c02\u9580\u533b\u306e\u8a8d\u5b9a\u306f\u3001\u5b66\u4f1a\u306b\u3088\u308b\u8a8d\u5b9a\u304b\u3089\u65e5\u672c\u5c02\u9580\u533b\u6a5f\u69cb\u306b\u3088\u308b\u8a8d\u5b9a\u3078\u3068\u79fb\u884c\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u816b\u760d\u5185\u79d1\u3092\u5fd7\u3059\u4eba\u306b\u3068\u3063\u3066\u306f\u3001\u300c\u5c02\u9580\u533b\u3092\u3069\u3046\u53d6\u308b\u304b\u300d\u3068\u3044\u3046\u5236\u5ea6\u305d\u306e\u3082\u306e\u304c\u3001\u3044\u307e\u307e\u3055\u306b\u6574\u3048\u3089\u308c\u3066\u3044\u308b\u6642\u671f\u306b\u3042\u305f\u308a\u307e\u3059\u3002<\/span>
\n\u51fa\u5178\uff1a\u65e5\u672c\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\uff08\u5c02\u9580\u533b\u5236\u5ea6\u306b\u95a2\u3059\u308b\u8aac\u660e\u4f1a\u30fb2026\u5e747\u670816\u65e5\u958b\u50ac\uff09<\/a><\/small><\/p>\n
\n\u25a0 \u4eca\u9031\u306e\u4e00\u5831\uff08\u6ce8\u76ee\u8ad6\u6587\uff09\uff0f\u4e73\u304c\u3093\u30fb\u7cbe\u5bc6\u533b\u7642<\/h2>\n
\nN Engl J Med. 2025;393(6):569\u2013580.\uff08\u7b2cIII\u76f8\u30fb\u56fd\u969b\u591a\u65bd\u8a2d\u30fb\u4e8c\u91cd\u76f2\u691c\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff0fNCT04964934\uff09<\/small><\/span><\/p>\n
\n\u30fb ESR1\u5909\u7570\u304c\u65b0\u305f\u306b\u73fe\u308c\u3001\u304b\u3064\u753b\u50cf\u4e0a\u306f\u307e\u3060\u9032\u884c\u3057\u3066\u3044\u306a\u3044315\u4f8b\u30921:1\u3067\u5272\u308a\u4ed8\u3051\u3001CDK4\/6\u963b\u5bb3\u85ac\u306f\u7d9a\u3051\u305f\u307e\u307e\u3001\u30a2\u30ed\u30de\u30bf\u30fc\u30bc\u963b\u5bb3\u85ac\u3092\u30ab\u30df\u30bc\u30b9\u30c8\u30e9\u30f3\u30c8\u306b\u5207\u308a\u66ff\u3048\u308b\u7fa4\u3068\u3001\u305d\u306e\u307e\u307e\u7d99\u7d9a\u3059\u308b\u7fa4\u3092\u6bd4\u8f03\u3057\u307e\u3057\u305f\u3002
\n\u30fb \u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff08\u4e2d\u592e\u5024\uff09\u306f\u3001\u5207\u66ff\u7fa416.0\u304b\u6708 \u5bfe \u7d99\u7d9a\u7fa49.2\u304b\u6708\uff08\u30cf\u30b6\u30fc\u30c9\u6bd40.44\u300195%CI 0.31\u20130.60\u3001P<0.0001\uff09\u3002QOL\u304c\u60aa\u5316\u3059\u308b\u307e\u3067\u306e\u671f\u9593\u308221.0\u304b\u6708 \u5bfe 6.4\u304b\u6708\u3068\u5ef6\u9577\u3057\u3001\u6709\u5bb3\u4e8b\u8c61\u306b\u3088\u308b\u4e2d\u6b62\u306f1.3% \u5bfe 1.9%\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002\u65e5\u672c\u306e\u65bd\u8a2d\u3082\u53c2\u52a0\u3057\u305f\u8a66\u9a13\u3067\u3059\u3002<\/p>\n
\n\u51fa\u5178\uff08PubMed\u53ce\u8f09\uff09\uff1aDOI: 10.1056\/NEJMoa2502929<\/a>\uff08Bidard FC, et al. N Engl J Med 2025\uff09<\/small><\/p>\n
\n\u25a0 \u5b66\u4f1a\u30fb\u30bb\u30df\u30ca\u30fc\uff0f\u884c\u4e8b<\/h2>\n
\n\u81e8\u5e8a\u7814\u7a76\u3067\u4f7f\u3046\u7d71\u8a08\u306e\u8003\u3048\u65b9\u3092\u3001\u57fa\u790e\u304b\u3089\u5b66\u3076\u30bb\u30df\u30ca\u30fc\u3002\u4eca\u56de\u306e\u30c6\u30fc\u30de\u306f\u300c\u591a\u91cd\u6bd4\u8f03\u300d\u3002\u30bb\u30df\u30ca\u30fc\u5f8c\u306b\u306f\u7d71\u8a08\u306e\u500b\u5225\u76f8\u8ac7\u306e\u6642\u9593\u3082\u8a2d\u3051\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u30c6\u30fc\u30de\uff1a<\/strong>\u591a\u91cd\u6bd4\u8f03
\n\u8b1b\u5e2b\uff1a<\/strong>\u85e4\u7530 \u6674\u5eb7 \u5148\u751f\uff08\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8 \u516c\u8846\u885b\u751f\u5b66 \u5ba2\u54e1\u6559\u6388\uff09
\n\u65e5\u6642\uff1a<\/strong>2026\u5e748\u67088\u65e5\uff08\u571f\uff0914:30\u301c
\n\u4f1a\u5834\uff1a<\/strong>\u7fa4\u99ac\u5927\u5b66\uff08Web\u914d\u4fe1\u3042\u308a\u30fb\u4efb\u610f\u53c2\u52a0\uff09
\n\u4e3b\u50ac\uff1a<\/strong>\u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u5730\u57df\u533b\u7642\u7814\u7a76\u30fb\u6559\u80b2\u30bb\u30f3\u30bf\u30fc\u4e8b\u52d9\u5c40
\n\u7533\u8fbc\uff1a<\/strong>2026\u5e747\u670824\u65e5\uff08\u91d1\uff09\u307e\u3067\uff08\u7d71\u8a08\u500b\u5225\u76f8\u8ac7\u3042\u308a\uff09
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u8ad6\u6587\u3092\u8aad\u307f\u30fb\u66f8\u304f\u3046\u3048\u3067\u6b20\u304b\u305b\u306a\u3044\u7d71\u8a08\u30ea\u30c6\u30e9\u30b7\u30fc\u3092\u3001\u57fa\u790e\u304b\u3089\u5b66\u3079\u308b\u6a5f\u4f1a\u3067\u3059\u3002<\/span><\/p>\n
\n\u25a0 \u3072\u3068\u3053\u3068\u30b3\u30e9\u30e0 \u2015 \u300c\u30ea\u30ad\u30c3\u30c9\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u300d\u3063\u3066\u4f55\u3092\u3057\u3066\u3044\u308b\u306e\uff1f<\/h2>\n
\n
\n\u203b\u63b2\u8f09\u5185\u5bb9\u30fb\u51fa\u5178\u306f\u4f5c\u6210\u6642\u70b9\u306e\u60c5\u5831\u306b\u57fa\u3065\u304d\u307e\u3059\u3002<\/small><\/p>\n","protected":false},"excerpt":{"rendered":"