{"id":2555,"date":"2026-07-16T15:13:23","date_gmt":"2026-07-16T06:13:23","guid":{"rendered":"https:\/\/oncoc.showa.gunma-u.ac.jp\/?p=2555"},"modified":"2026-07-21T14:44:43","modified_gmt":"2026-07-21T05:44:43","slug":"%e4%bb%8a%e9%80%b1%e3%81%ae%e8%85%ab%e7%98%8d%e5%86%85%e7%a7%91%ef%bc%887-6-7-12%ef%bc%89","status":"publish","type":"post","link":"https:\/\/oncoc.showa.gunma-u.ac.jp\/?p=2555","title":{"rendered":"\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\uff087\/6\u20137\/12\uff09"},"content":{"rendered":"

\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1<\/h1>\n

2026\u5e747\u6708\u7b2c2\u9031\uff087\/6\u20137\/12\uff09\uff0f \u7fa4\u99ac\u5927\u5b66\u533b\u5b66\u90e8\u9644\u5c5e\u75c5\u9662 \u816b\u760d\u5185\u79d1<\/p>\n

 <\/p>\n

\u816b\u760d\u5185\u79d1\u3092\u5fd7\u3059\u533b\u5b66\u751f\u30fb\u7814\u4fee\u533b\u306e\u307f\u306a\u3055\u3093\u3078\u3002\u5f53\u79d1\u306e\u4e00\u9031\u9593\u306e\u69d8\u5b50\u3068\u3001\u304c\u3093\u85ac\u7269\u7642\u6cd5\u3092\u3081\u3050\u308b\u4e16\u306e\u4e2d\u306e\u52d5\u304d\u3092\u3001\u5148\u8f29\u533b\u5e2b\u306e\u76ee\u7dda\u3067\u307e\u3068\u3081\u3066\u304a\u5c4a\u3051\u3057\u307e\u3059\u3002<\/p>\n

\u4eca\u9031\u306f\u300c\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u3066\u6cbb\u7642\u3092\u9078\u3076\u300d\u7cbe\u5bc6\u533b\u7642\u306e\u8a71\u984c\u304c\u7d9a\u304d\u307e\u3059\u3002\u80a9\u306e\u529b\u3092\u629c\u3044\u3066\u8aad\u3093\u3067\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n

\n

\u4eca\u9031\u306e\u5f53\u79d1\u304b\u3089<\/h2>\n

\u25a0\u816b\u760d\u30bb\u30f3\u30bf\u30fc\u30fb\u7de9\u548c\u30b1\u30a2\u30bb\u30f3\u30bf\u30fc\u306e\u904b\u55b6\u59d4\u54e1\u4f1a<\/strong>
\n\u75c5\u9662\u5168\u4f53\u306e\u304c\u3093\u8a3a\u7642\u4f53\u5236\u3084\u3001\u7de9\u548c\u30b1\u30a2\u306e\u63d0\u4f9b\u72b6\u6cc1\u3092\u3001\u591a\u8077\u7a2e\u3067\u5171\u6709\u30fb\u691c\u8a0e\u3059\u308b\u5b9a\u4f8b\u306e\u59d4\u54e1\u4f1a\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u816b\u760d\u5185\u79d1\u533b\u304c\u3001\u500b\u3005\u306e\u8a3a\u7642\u3060\u3051\u3067\u306a\u304f\u75c5\u9662\u5168\u4f53\u306e\u304c\u3093\u533b\u7642\u306e\u4ed5\u7d44\u307f\u3065\u304f\u308a\u306b\u3082\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/span>
\n\u25a0\u5316\u5b66\u7642\u6cd5\u30ec\u30b8\u30e1\u30f3\u306e\u5be9\u67fb\uff08\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u5be9\u67fb\u59d4\u54e1\u4f1a\uff09<\/strong>
\n\u65b0\u3057\u3044\u6297\u304c\u3093\u5264\u6cbb\u7642\u306e\u8a08\u753b\uff08\u30ec\u30b8\u30e1\u30f3\uff09\u3092\u3001\u6709\u52b9\u6027\u30fb\u5b89\u5168\u6027\u306e\u89b3\u70b9\u304b\u3089\u4f7f\u7528\u958b\u59cb\u524d\u306b\u5be9\u67fb\u3059\u308b\u4f1a\u8b70\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u6297\u304c\u3093\u5264\u6cbb\u7642\u3092\u300c\u5b89\u5168\u306b\u5c4a\u3051\u308b\u300d\u305f\u3081\u306e\u3001\u6a19\u6e96\u5316\u3068\u7ba1\u7406\u306e\u8003\u3048\u65b9\u306b\u89e6\u308c\u3089\u308c\u307e\u3059\u3002<\/span>
\n\u25a0\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\uff0f\u30a8\u30ad\u30b9\u30d1\u30fc\u30c8\u30d1\u30cd\u30eb<\/strong>
\n\u304c\u3093\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306e\u7d50\u679c\u3092\u3001\u4ed6\u65bd\u8a2d\u3068\u3082\u5408\u540c\u3067\u591a\u8077\u7a2e\u30fb\u591a\u8a3a\u7642\u79d1\u3067\u8aad\u307f\u89e3\u3044\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u907a\u4f1d\u5b50\u306e\u60c5\u5831\u3092\u6cbb\u7642\u9078\u629e\u306b\u3064\u306a\u3052\u308b\u7cbe\u5bc6\u533b\u7642\u306e\u73fe\u5834\u3092\u3001\u9593\u8fd1\u3067\u898b\u3089\u308c\u307e\u3059\uff08\u4eca\u9031\u306e\u4e00\u5831\u3068\u3082\u95a2\u308f\u308b\u8a71\u984c\u3067\u3059\uff09\u3002<\/span>
\n\u25a0\u5316\u5b66\u7642\u6cd5\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\uff08\u6d88\u5316\u7ba1\u30fb\u809d\u80c6\u81b5\uff09<\/strong>
\n\u5916\u79d1\u3084\u591a\u8077\u7a2e\u3068\u4e00\u7dd2\u306b\u3001\u4e00\u4eba\u3072\u3068\u308a\u306e\u6cbb\u7642\u65b9\u91dd\u3092\u6301\u3061\u5bc4\u3063\u3066\u76f8\u8ac7\u3059\u308b\u5b9a\u4f8b\u306e\u30ab\u30f3\u30d5\u30a1\u30ec\u30f3\u30b9\u3067\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u624b\u8853\u30fb\u85ac\u7269\u7642\u6cd5\u30fb\u652f\u6301\u7642\u6cd5\u3092\u898b\u6e21\u3057\u3066\u6cbb\u7642\u3092\u7d44\u307f\u7acb\u3066\u308b\u3001\u305d\u306e\u8003\u3048\u65b9\u306e\u5b9f\u969b\u306b\u89e6\u308c\u3089\u308c\u307e\u3059\u3002<\/span>
\n\u25a0\u7d99\u7d9a\u5b66\u7fd2\uff08Web\u8b1b\u6f14\u4f1a\u306a\u3069\uff09<\/strong>
\n\u80c6\u9053\u304c\u3093\u306e\u85ac\u7269\u7642\u6cd5\u3092\u306f\u3058\u3081\u3001\u5e45\u5e83\u3044\u9818\u57df\u306e\u6700\u65b0\u77e5\u898b\u3092\u6271\u3046\u30aa\u30f3\u30e9\u30a4\u30f3\u8b1b\u6f14\u4f1a\u306b\u3082\u968f\u6642\u53c2\u52a0\u3057\u3066\u3044\u307e\u3059\u3002
\n\u5b66\u3073\u3069\u3053\u308d\uff1a\u65e5\u3005\u66f4\u65b0\u3055\u308c\u308b\u77e5\u8b58\u3092\u8ffd\u3044\u7d9a\u3051\u308b\u3001\u816b\u760d\u5185\u79d1\u306e\u5b66\u3073\u306e\u6587\u5316\u304c\u4f1d\u308f\u308c\u3070\u3068\u601d\u3044\u307e\u3059\u3002<\/span><\/p>\n

 <\/p>\n

\u203b \u500b\u3005\u306e\u60a3\u8005\u3055\u3093\u30fb\u75c7\u4f8b\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u542b\u307f\u307e\u305b\u3093\u3002\u5f53\u79d1\u306e\u6d3b\u52d5\u3092\u4e00\u822c\u5316\u3057\u3066\u3054\u7d39\u4ecb\u3057\u3066\u3044\u307e\u3059\u3002<\/small><\/p>\n

\n

\u4eca\u9031\u306e\u816b\u760d\u5185\u79d1\u30cb\u30e5\u30fc\u30b9<\/h2>\n

\u25a0\u30a4\u30dc\u30b7\u30c7\u30cb\u30d6\uff08\u30c6\u30a3\u30d6\u30bd\u30dc\uff09\u3001IDH1\u5909\u7570\u967d\u6027\u306e\u80c6\u9053\u304c\u3093\u306b\u627f\u8a8d\u3000<\/strong>\u85ac\u4e8b\u627f\u8a8d<\/span><\/small><\/p>\n

\u5bfe\u8c61\uff1a\u304c\u3093\u907a\u4f1d\u5b50\u691c\u67fb\u3067 IDH1 \u907a\u4f1d\u5b50\u5909\u7570\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3001\u6cbb\u7652\u5207\u9664\u4e0d\u80fd\u306a\u80c6\u9053\u304c\u3093\uff08\u65e2\u6cbb\u7642\u4f8b\uff09\u3002\u9069\u5fdc\u62e1\u5927\uff08\u52b9\u80fd\u8ffd\u52a0\uff09\u3068\u3057\u3066\u30012026\u5e746\u670819\u65e5\u306b\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u203b\u73fe\u6642\u70b9\u3067\u306f\u85ac\u4e8b\u627f\u8a8d\u306e\u6bb5\u968e\u3067\u3001\u4fdd\u967a\u9069\u7528\uff08\u85ac\u4fa1\u53ce\u8f09\uff09\u306f\u3053\u306e\u5f8c\u306e\u624b\u7d9a\u304d\u306b\u306a\u308a\u307e\u3059\u3002<\/div>\n
\u5b66\u3073\u3069\u3053\u308d\uff1a\u304c\u3093\u30b2\u30ce\u30e0\uff08\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\uff09\u691c\u67fb\u3067\u898b\u3064\u304b\u308b\u907a\u4f1d\u5b50\u7570\u5e38\u304c\u3001\u305d\u306e\u307e\u307e\u6cbb\u7642\u85ac\u306e\u9078\u629e\u306b\u3064\u306a\u304c\u308b\u2015\u7cbe\u5bc6\u533b\u7642\u304c\u5e0c\u5c11\u304c\u3093\u306b\u3082\u5e83\u304c\u3063\u3066\u304d\u305f\u4e00\u5831\u3067\u3059\u3002\u88cf\u4ed8\u3051\u3068\u306a\u3063\u305f\u8a66\u9a13\u306f\u4e0b\u306e\u300c\u4eca\u9031\u306e\u4e00\u5831\u300d\u3067\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/span><\/div>\n

\u51fa\u5178 \uff1a \u65b0\u85ac\u60c5\u5831\u30aa\u30f3\u30e9\u30a4\u30f3\uff082026\u5e746\u670819\u65e5\u627f\u8a8d\u54c1\u76ee\uff09<\/a>\uff08\u6bb5\u968e\u30fb\u6210\u5206\u540d\u306e\u6700\u7d42\u78ba\u8a8d\u306f\u4e00\u6b21\u60c5\u5831\u3014PMDA\u30fb\u539a\u52b4\u7701\u3015\u3067\uff09<\/small><\/p>\n

\n
\u25a0\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u3001\u62e0\u70b9\u75c5\u9662\u306e\u6307\u5b9a\u8981\u4ef6\u3092\u898b\u76f4\u3057\uff08\u539a\u52b4\u7701WG\uff09<\/strong><\/div>\n
\u539a\u751f\u52b4\u50cd\u7701\u306e\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7\u3067\u3001\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u62e0\u70b9\u75c5\u9662\u3092\u5168\u90fd\u9053\u5e9c\u770c\u306b\u6574\u5099\u3059\u308b\u65b9\u91dd\u3084\u3001\u304c\u3093\u8a3a\u7642\u9023\u643a\u62e0\u70b9\u75c5\u9662\u3067\u306a\u304f\u3066\u3082\u30b2\u30ce\u30e0\u533b\u7642\u306e\u300c\u9023\u643a\u75c5\u9662\u300d\u306b\u6307\u5b9a\u3067\u304d\u308b\u3088\u3046\u306b\u3059\u308b\u65b9\u5411\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u4f4f\u3080\u5730\u57df\u306b\u3088\u3089\u305a\u3001\u907a\u4f1d\u5b50\u30d1\u30cd\u30eb\u691c\u67fb\u306b\u30a2\u30af\u30bb\u30b9\u3067\u304d\u308b\u4f53\u5236\u3065\u304f\u308a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/div>\n

\u51fa\u5178\uff1aGemMed\u300c\u304c\u3093\u30b2\u30ce\u30e0\u533b\u7642\u62e0\u70b9\u75c5\u9662\u3092\u5168\u90fd\u9053\u5e9c\u770c\u306b\u6574\u5099\u2026\u2014\u304c\u3093\u30b2\u30ce\u30e0\u62e0\u70b9\u75c5\u9662\u6307\u5b9a\u8981\u4ef6WG\u300d\uff082026\u5e747\u67087\u65e5\uff09<\/a><\/small><\/p>\n

\n

\u4eca\u9031\u306e\u4e00\u5831\uff08\u6ce8\u76ee\u8ad6\u6587\uff09\uff1a\u80c6\u9053\u304c\u3093<\/h2>\n

\u25a0IDH1\u5909\u7570\u967d\u6027\u306e\u80c6\u9053\u304c\u3093\u306b\u5bfe\u3059\u308b\u30a4\u30dc\u30b7\u30c7\u30cb\u30d6\uff08ClarIDHy \u8a66\u9a13\uff09<\/strong>
\nLancet Oncol. 2020;21(6):796\u2013807.\uff08\u7b2cIII\u76f8\u30fb\u4e8c\u91cd\u76f2\u691c\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\uff09\uff0f \u6700\u7d42\u5168\u751f\u5b58\u306e\u89e3\u6790\uff1aJAMA Oncol. 2021;7(11):1669\u20131677.<\/span><\/small>
\n\u2022\u3000\u809d\u5185\u80c6\u7ba1\u304c\u3093\u306e\u7d0413%\u306b IDH1 \u907a\u4f1d\u5b50\u5909\u7570\u304c\u307f\u3089\u308c\u307e\u3059\u3002\u65e2\u6cbb\u7642\u306e IDH1 \u5909\u7570\u967d\u6027\u30fb\u9032\u884c\u80c6\u9053\u304c\u3093\u3092\u5bfe\u8c61\u306b\u3001IDH1 \u963b\u5bb3\u85ac\u30a4\u30dc\u30b7\u30c7\u30cb\u30d6\u3092\u30d7\u30e9\u30bb\u30dc\u3068\u6bd4\u8f03\u3057\u307e\u3057\u305f\uff082:1 \u5272\u4ed8\u3001\u8a08185\u4f8b\uff09\u3002
\n\u2022\u3000\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u306e\u7121\u5897\u60aa\u751f\u5b58\u671f\u9593\uff08\u4e2d\u592e\u5024\uff09\u306f 2.7\u304b\u6708 \u5bfe 1.4\u304b\u6708\uff08\u30cf\u30b6\u30fc\u30c9\u6bd4 0.37\u300195%CI 0.25\u20130.54\u3001\u7247\u5074 P<0.0001\uff09\u3068\u3001\u30a4\u30dc\u30b7\u30c7\u30cb\u30d6\u7fa4\u3067\u6709\u610f\u306b\u826f\u597d\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002
\n\u2022\u3000\u5168\u751f\u5b58\u671f\u9593\u306e\u4e2d\u592e\u5024\u306f 10.3\u304b\u6708 \u5bfe 7.5\u304b\u6708\u3002\u75c5\u52e2\u9032\u884c\u5f8c\u306b\u30d7\u30e9\u30bb\u30dc\u7fa4\u304b\u3089\u5b9f\u85ac\u3078\u79fb\u3063\u305f\u4f8b\uff0843\u4f8b\uff09\u3092\u88dc\u6b63\u3059\u308b\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u306e\u751f\u5b58\u671f\u9593\u4e2d\u592e\u5024\u306f 5.1\u304b\u6708\u3001\u30cf\u30b6\u30fc\u30c9\u6bd4 0.49\uff0895%CI 0.34\u20130.70\u3001\u7247\u5074 P<0.001\uff09\u3067\u3057\u305f\u3014\u8ad6\u6587\u5831\u544a\u5024\u3015\u3002<\/p>\n

\u81e8\u5e8a\u7684\u610f\u7fa9\uff1a\u907a\u4f1d\u5b50\u5909\u7570\u3092\u72d9\u3044\u6483\u3064\u300c\u6a19\u7684\u6cbb\u7642\u300d\u3092\u3001\u5e0c\u5c11\u304c\u3093\u3067\u3042\u308b\u80c6\u9053\u304c\u3093\u306b\u3082\u5c4a\u3051\u305f\u4e00\u672c\u3067\u3059\u3002\u30d1\u30cd\u30eb\u691c\u67fb \u2192 \u5909\u7570\u306e\u540c\u5b9a \u2192 \u6cbb\u7642\u3001\u3068\u3044\u3046\u30b2\u30ce\u30e0\u533b\u7642\u306e\u6d41\u308c\u304c\u3001\u305d\u306e\u307e\u307e\u81e8\u5e8a\u306b\u52b9\u3044\u3066\u304f\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3059\u3002<\/span>
\n\u51fa\u5178\uff08PubMed \u53ce\u8f09\uff09\uff1aDOI: 10.1016\/S1470-2045(20)30157-1<\/a>\uff08Abou-Alfa GK, et al. Lancet Oncol 2020\uff09\uff0f\u00a0DOI: 10.1001\/jamaoncol.2021.3836<\/a>\uff08Zhu AX, et al. JAMA Oncol 2021\uff09<\/small><\/p>\n

\n

\u5b66\u4f1a\u30fb\u30bb\u30df\u30ca\u30fc\uff0f\u884c\u4e8b<\/h2>\n

\u25a07\/13\uff08\u6708\uff09Colorectal Cancer Genomic Seminar in Gunma<\/strong>
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\n

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\n

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